2020
Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets
Achanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.Peer-Reviewed Original ResearchConceptsChemical injuryTRP channelsNeurogenic inflammatory pathwaysChemical threat agentsMediator of injuryTransient receptor potential channelsTransient receptor potential (TRP) ion channelsIntracellular calcium levelsToxic inhalation hazardPotential ion channelsCough reflexPulmonary injuryPulmonary edemaProinflammatory cellsInflammatory pathwaysPathophysiologic eventsOccupational exposureMucus clearanceCalcium levelsInjuryNonneuronal pathwaysRespiratory systemBroader indicationsPotential channelsInhalation hazard
2017
Perioperative Outcomes of Open versus Endovascular Repair for Ruptured Thoracoabdominal Aneurysms
Locham S, Grimm J, Arhuidese I, Nejim B, Obeid T, Black J, Malas M. Perioperative Outcomes of Open versus Endovascular Repair for Ruptured Thoracoabdominal Aneurysms. Annals Of Vascular Surgery 2017, 44: 128-135. PMID: 28501656, DOI: 10.1016/j.avsg.2017.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Aneurysm, ThoracicAortic RuptureBlood Vessel Prosthesis ImplantationChi-Square DistributionComorbidityDatabases, FactualEndovascular ProceduresFemaleHumansLogistic ModelsMaleMultivariate AnalysisOdds RatioOperative TimePostoperative ComplicationsRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsOpen aneurysm repairEndovascular repairRenal failureAneurysm repairPostoperative outcomesPulmonary injuryNational Surgical Quality Improvement Program databaseRisk of renal failureQuality Improvement Program databaseRuptured thoracoabdominal aortic aneurysmThoracoabdominal aortic aneurysmsHigh-risk patient characteristicsEndovascular aneurysm repairAssociated with higher ratesTAAA repairPulmonary complicationsPerioperative outcomesCardiopulmonary complicationsEndovascular approachAortic aneurysmProgram databaseIdentified patientsContemporary outcomesPatient characteristicsOperative time
2012
Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
Tejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. Journal Of Medical Genetics 2012, 49: 671. PMID: 23048207, PMCID: PMC3654537, DOI: 10.1136/jmedgenet-2012-100972.Peer-Reviewed Original ResearchConceptsAcute lung injuryALI/ARDSIndirect lung injuryRisk of ARDSRespiratory distress syndromeLung injuryExtrapulmonary causesDistress syndromeIndirect insultsSingle nucleotide polymorphismsStage IIAcute respiratory distress syndromeDevelopment of ARDSGenetic variantsGenetic risk factorsIll Caucasian patientsFunctional single nucleotide polymorphismsALI/Extrapulmonary injuryPulmonary sepsisPulmonary injuryExtrapulmonary originCaucasian patientsRisk factorsARDS
2011
A New Shield for a Cytokine Storm
Iwasaki A, Medzhitov R. A New Shield for a Cytokine Storm. Cell 2011, 146: 861-862. PMID: 21925310, PMCID: PMC3645871, DOI: 10.1016/j.cell.2011.08.027.Peer-Reviewed Original Research
2010
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, Thannickal VJ, Kaminski N, Abraham E. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. Journal Of Experimental Medicine 2010, 207: 1589-1597. PMID: 20643828, PMCID: PMC2916139, DOI: 10.1084/jem.20100035.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAntisense Elements (Genetics)BleomycinCell LineCollagenExtracellular Matrix ProteinsFibroblastsFibronectinsGene ExpressionHumansIdiopathic Pulmonary FibrosisLungMiceMice, Inbred C57BLMice, TransgenicMicroRNAsOligonucleotidesPhosphorylationPulmonary FibrosisSmad2 ProteinSmad7 ProteinTransforming Growth Factor beta1ConceptsIdiopathic pulmonary fibrosisFibrotic lung diseaseMiR-21 expressionMiR-21Fibrotic diseasesLung diseaseLung fibrosisPulmonary fibroblastsPrimary pulmonary fibroblastsPro-fibrogenic activityLungs of patientsLungs of miceExperimental lung fibrosisMiR-21 levelsPulmonary injuryInjury contributesPulmonary fibrosisPathological mediatorsPathophysiologic processesDysregulation of miRNAsFibrogenic activationFibrosisDiseaseExtracellular matrix productionFatal process
2005
Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer
Burstein HJ, Bellon JR, Galper S, Lu HM, Kuter I, Taghian AG, Wong J, Gelman R, Bunnell CA, Parker LM, Garber JE, Winer EP, Harris JR, Powell SN. Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer. International Journal Of Radiation Oncology • Biology • Physics 2005, 64: 496-504. PMID: 16243442, DOI: 10.1016/j.ijrobp.2005.07.975.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsChemotherapy, AdjuvantCyclophosphamideDoxorubicinDrug Administration ScheduleFeasibility StudiesFemaleHumansPaclitaxelProspective StudiesRadiation PneumonitisRadiation-Sensitizing AgentsRadiotherapy DosageRadiotherapy, AdjuvantConceptsRadiation therapyBreast cancerAdjuvant doxorubicinConcurrent paclitaxelWeekly paclitaxelAC chemotherapyConcurrent radiationConcurrent treatmentGrade 2 radiation pneumonitisStage IIEarly-stage breast cancerAdjuvant AC chemotherapyDefinitive breast surgeryOperable stage IIWeekly paclitaxel treatmentConcurrent radiation therapyDose-limiting toxicityProtocol-based treatmentAdjuvant chemotherapyPaclitaxel scheduleSteroid therapyCyclophosphamide chemotherapyRadiation pneumonitisPulmonary injuryRadiation dermatitis
2004
Regulation of pulmonary fibrosis by chemokine receptor CXCR3
Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. Journal Of Clinical Investigation 2004, 114: 291-299. PMID: 15254596, PMCID: PMC449741, DOI: 10.1172/jci16861.Peer-Reviewed Original ResearchConceptsCXC chemokine receptor 3Lung NK cellsCXCR3-deficient miceIFN-gamma productionLung injuryIFN-gammaEnhanced fibrosisNK cellsWT miceChemokine receptors CXC chemokine receptor 3Chemokine MIG/CXCL9Endogenous IFN-gamma productionI-TAC/CXCL11IP-10/CXCL10Inflammatory cell recruitmentProgressive interstitial fibrosisChemokine receptor 3Exogenous IFN-gammaExpression of CXCL10MIG/CXCL9CXCR3 deficiencyAdoptive transferPulmonary injuryLymph nodesPulmonary fibrosis
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