2020
An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis
Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Journal Of Allergy And Clinical Immunology 2020, 145: 550-562. PMID: 32035607, PMCID: PMC8440091, DOI: 10.1016/j.jaci.2019.10.031.Peer-Reviewed Original ResearchConceptsMiR-1 levelsAllergic airway inflammationChronic rhinosinusitisP-selectin levelsEndothelium-specific overexpressionLung endotheliumAirway eosinophiliaAirway inflammationAsthmatic patientsTissue eosinophiliaMiR-1House dust mite modelEndothelial cellsThymic stromal lymphopoietinNumber of hospitalizationsHuman lung endotheliumIL-13 stimulationCRS cohortQuantitative RT-PCRSputum eosinophiliaAirway obstructionAsthma modelAsthma phenotypesLentiviral vector deliveryMurine model
2013
Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype
Tyagi T, Ahmad S, Gupta N, Sahu A, Ahmad Y, Nair V, Chatterjee T, Bajaj N, Sengupta S, Ganju L, Singh SB, Ashraf MZ. Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype. Blood 2013, 123: 1250-1260. PMID: 24297866, DOI: 10.1182/blood-2013-05-501924.Peer-Reviewed Original ResearchConceptsCalpain activityPlatelet reactivityProthrombotic phenotypeThrombus formationSoluble P-selectin levelsIncidence of thrombosisP-selectin levelsProthrombotic rolePlatelet hyperreactivitySolid tumorsVivo modelSmall subunit 1ThrombosisPathological conditionsAltered expressionHypoxic conditionsHypoxic environmentPlatelet proteinsHypoxiaExtreme altitudePresent studyCalpain functionPlateletsSubunit 1Phenotype
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