2021
The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review
Tizaoui K, Terrazzino S, Cargnin S, Lee K, Gauckler P, Li H, Shin J, Kronbichler A. The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review. Seminars In Arthritis And Rheumatism 2021, 51: 513-522. PMID: 33866147, DOI: 10.1016/j.semarthrit.2021.03.004.Peer-Reviewed Original ResearchConceptsPTPN22 geneGenetic association studiesProtein tyrosine phosphataseAutoimmune diseasesGenetic risk factorsAssociation studiesTyrosine phosphataseDevelopment of immune dysfunctionBiological processesImmune systemIncidence of autoimmune diseasesMolecular mechanismsAdaptive immune systemPathogenesis of autoimmune diseasesPotential therapeutic targetNatural killer cellsGenesPTPN22PTPN22 variantInnate immune cellsSystemic lupus erythematosusMultiple autoimmune disordersCell typesPrevalent autoimmune diseasesAssociated with rheumatoid arthritis
2019
Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach
Tizaoui K, Kim S, Jeong G, Kronbichler A, Lee K, Lee K, Shin J. Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach. Journal Of Clinical Medicine 2019, 8: 347. PMID: 30871019, PMCID: PMC6462981, DOI: 10.3390/jcm8030347.Peer-Reviewed Original ResearchGenome-wide association studiesMeta-analysis of genome-wide association studiesGenetic associationObservational studyMeta-analysisAssociation studiesGenetic variantsBayesian approachPTPN22 1858C/T polymorphismSystematic reviewMeta-analysesSignificant associationAutoimmune diseasesPolymorphismRelevant publicationsAssociationPubMed searchFalse positive resultsLociBayesian methodsNOTEWORTHYPTPN22ProteinDiseasePubMedPTPN22 +788 G>A (R263Q) Polymorphism is Associated with mRNA Expression but it is not a Susceptibility Marker for Rheumatoid Arthritis Patients from Western Mexico
Ramírez-Pérez S, Sánchez-Zuno G, Chavarría-Buenrostro L, Montoya-Buelna M, Reyes-Pérez I, Ramírez-Dueñas M, Palafox-Sánchez C, Martínez-Bonilla G, Muñoz-Valle J. PTPN22 +788 G>A (R263Q) Polymorphism is Associated with mRNA Expression but it is not a Susceptibility Marker for Rheumatoid Arthritis Patients from Western Mexico. Biochemical Genetics 2019, 57: 455-465. PMID: 30637604, DOI: 10.1007/s10528-019-09902-8.Peer-Reviewed Original ResearchConceptsWestern Mexican populationPolymerase chain reaction-restriction fragment length polymorphismRA patientsControl subjectsMRNA expressionG/A genotypeRA susceptibilityReal-time quantitative-PCR assayAssociated with RA susceptibilityRheumatoid arthritisMexican populationReaction-restriction fragment length polymorphismHomozygous G/G genotypeAssociated with mRNA expressionCase-control studyNon-HLA genesAssociated with rheumatoid arthritisRheumatoid arthritis patientsG/G genotypeSusceptibility markersCaucasian populationPatientsPTPN22Quantitative-PCR assayRA risk
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