The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review
Tizaoui K, Terrazzino S, Cargnin S, Lee K, Gauckler P, Li H, Shin J, Kronbichler A. The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review. Seminars In Arthritis And Rheumatism 2021, 51: 513-522. PMID: 33866147, DOI: 10.1016/j.semarthrit.2021.03.004.Peer-Reviewed Original ResearchConceptsPTPN22 geneGenetic association studiesProtein tyrosine phosphataseAutoimmune diseasesGenetic risk factorsAssociation studiesTyrosine phosphataseDevelopment of immune dysfunctionBiological processesImmune systemIncidence of autoimmune diseasesMolecular mechanismsAdaptive immune systemPathogenesis of autoimmune diseasesPotential therapeutic targetNatural killer cellsGenesPTPN22PTPN22 variantInnate immune cellsSystemic lupus erythematosusMultiple autoimmune disordersCell typesPrevalent autoimmune diseasesAssociated with rheumatoid arthritis
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