2024
Proteogenomic characterization of pancreatic neuroendocrine tumors uncovers hypoxia and immune signatures in clinically aggressive subtypes
Tanaka A, Ogawa M, Zhou Y, Otani Y, Hendrickson R, Miele M, Li Z, Klimstra D, Wang J, Roehrl M. Proteogenomic characterization of pancreatic neuroendocrine tumors uncovers hypoxia and immune signatures in clinically aggressive subtypes. IScience 2024, 27: 110544. PMID: 39206147, PMCID: PMC11350455, DOI: 10.1016/j.isci.2024.110544.Peer-Reviewed Original ResearchClinically aggressive subtypePancreatic neuroendocrine tumorsProteomic subtypesNeuroendocrine tumorsAggressive subtypeImmune hot tumorsSystemic treatment optionsVariable clinical outcomesTumor grading systemPredicting patient outcomesHot tumorsCytotoxic chemotherapyImmune signaturesImmunosuppressive moleculesImmunotherapy targetClinical aggressivenessSomatostatin analogsRecurrence rateClinical outcomesTreatment optionsEndocrine neoplasmsGlycolysis upregulationPanNETsProteogenomic characterizationInflammatory pathways
2017
A meta-analysis of prognostic roles of molecular markers in papillary thyroid carcinoma
Vuong H, Duong U, Altibi A, Ngo H, Pham T, Tran H, Gandolfi G, Hassell L. A meta-analysis of prognostic roles of molecular markers in papillary thyroid carcinoma. Endocrine Connections 2017, 6: r8-r17. PMID: 28219937, PMCID: PMC5424840, DOI: 10.1530/ec-17-0010.Peer-Reviewed Original ResearchDisease-specific survivalDisease-free survivalPapillary thyroid carcinomaKaplan-Meier curvesPromoter mutationsHazard ratioPrognostic roleThyroid carcinomaData of hazard ratioVirtual Health LibraryAssess patient prognosisPooled hazard ratioInverse variance methodConfidence intervalsPrognosis of PTC patientsPredicting patient outcomesVisual inspection of funnel plotsMeta-analysesInspection of funnel plotsRandom-effects modelPrognostic valuePTC patientsEgger's regression testRisk stratificationPatient prognosis
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