2017
Angiotensin-converting Enzyme Inhibitor and Other Drug-associated Angioedema
Stone C, Brown NJ. Angiotensin-converting Enzyme Inhibitor and Other Drug-associated Angioedema. Immunology And Allergy Clinics Of North America 2017, 37: 483-495. PMID: 28687104, DOI: 10.1016/j.iac.2017.04.006.Peer-Reviewed Original ResearchConceptsDrug-induced angioedemaEnzyme inhibitorsAngiotensin-converting enzyme inhibitorNon-β-lactam antibioticsNonsteroidal antiinflammatory agentsNonallergic angioedemaSubstance PTherapeutic decisionsAngioedemaAntiinflammatory agentsLactam antibioticsOther DrugΒ-lactam antibioticsDrugsPatientsLeukotrienesBradykininGenetic variantsAntibioticsInhibitorsAngiotensinProstaglandinsAgentsHistamineMainstay
2010
Human immune responses in cryptosporidiosis
Borad A, Ward H. Human immune responses in cryptosporidiosis. Future Microbiology 2010, 5: 507-519. PMID: 20210556, PMCID: PMC2856646, DOI: 10.2217/fmb.09.128.Peer-Reviewed Original ResearchConceptsHuman immune responseImmune responseToll-like receptor pathwayCell-mediated responsesMucosal antibody responsesAdaptive immune responsesPutative protective antigensInnate immune responseMannose-binding lectinAntibody responseT cellsIFN-gammaCryptosporidium infectionTherapeutic interventionsReceptor pathwayProtective antigenCryptosporidiosisCritical roleResponseAntimicrobial peptidesChemokinesCytokinesFurther knowledgeProstaglandinsInfection
2008
(Pro)renin Receptor Activation Causes Acute Production of Macula Densa Prostaglandins
Meer E, Kang J, Vargas S, Toma I, Peti‐Peterdi J. (Pro)renin Receptor Activation Causes Acute Production of Macula Densa Prostaglandins. The FASEB Journal 2008, 22: 761.29-761.29. DOI: 10.1096/fasebj.22.1_supplement.761.29.Peer-Reviewed Original ResearchMacula densaPG synthesisCOX-2PG productionPGE2 EP1 receptorMD cellsMMDD1 cellsMAP kinases ERK1/2EP1 receptorAcute riseRenin expressionRenin synthesisFura-2PG releasePGE2 releaseReceptor activationAcute productionProstaglandinsWestern blotReninPathological conditionsGranular cellsReceptorsSignificant increaseHEK cells
2007
Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response
Lin ZP, Zhu YL, Johnson DR, Rice KP, Nottoli T, Hains BC, McGrath J, Waxman SG, Sartorelli AC. Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response. Molecular Pharmacology 2007, 73: 243-251. PMID: 17959714, PMCID: PMC2780335, DOI: 10.1124/mol.107.039594.Peer-Reviewed Original ResearchConceptsNociceptive responsesPG synthesisInflammatory nociceptive responsesInflammatory pain thresholdWild-type miceCyclooxygenase-2 expressionMrp4 knockout miceMultidrug resistance protein 4Accumulation of intracellularMEF cellsMRP4 knockdownNucleotide agentsPain thresholdDisruptions of cAMPPGE metabolitePG levelsEnergy-dependent effluxProtein 4MiceMRP4PG transportIntracellular levelsProstaglandinsATP-binding cassette (ABC) familyPronounced reduction
2006
Immunosuppressive Factors in Cancer
Moss J, Metz C, Bucala R. Immunosuppressive Factors in Cancer. 2006 DOI: 10.1002/3527600906.mcb.200400129.Peer-Reviewed Original ResearchImmunosuppressive factorsTumor cellsHost's antitumor defenseHost immune responseHost immune systemSuccessful cancer therapeuticsCancer patientsAntitumor defenseImmune responseEffective treatmentEvasive mechanismsImmune systemCell surface receptorsCancer therapeuticsSurface receptorsCancerCellsPatientsCytokinesProstaglandinsAntigenMajor obstacleReceptors
2001
COX-2 Inhibitors and the Kidney
Perazella M. COX-2 Inhibitors and the Kidney. Hospital Practice 2001, 36: 43-56. PMID: 11263799, DOI: 10.3810/hp.2001.03.230.Peer-Reviewed Original Research
1997
The prostaglandin transporter is widely expressed in ocular tissues
Schuster V, Lu R, Coca-Prados M. The prostaglandin transporter is widely expressed in ocular tissues. Survey Of Ophthalmology 1997, 41: s41-s45. PMID: 9154275, DOI: 10.1016/s0039-6257(97)80006-9.Peer-Reviewed Original Research
1995
Safety of Parenteral Hydroxypropyl β‐Cyclodextrin
Carpenter T, Gerloczy A, Pitha J. Safety of Parenteral Hydroxypropyl β‐Cyclodextrin. Journal Of Pharmaceutical Sciences 1995, 84: 222-225. PMID: 7738806, DOI: 10.1002/jps.2600840220.Peer-Reviewed Original Research
1989
Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedulla
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