2016
Genome-Wide Analysis of Polyadenylation Events in Schmidtea mediterranea
Lakshmanan V, Bansal D, Kulkarni J, Poduval D, Krishna S, Sasidharan V, Anand P, Seshasayee A, Palakodeti D. Genome-Wide Analysis of Polyadenylation Events in Schmidtea mediterranea. G3: Genes, Genomes, Genetics 2016, 6: 3035-3048. PMID: 27489207, PMCID: PMC5068929, DOI: 10.1534/g3.116.031120.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAnimalsComputational BiologyGenome, HelminthGenome-Wide Association StudyHigh-Throughput Nucleotide SequencingMicroRNAsMolecular Sequence AnnotationPlatyhelminthsPoly APolyadenylationReproducibility of ResultsRNA InterferenceRNA Processing, Post-TranscriptionalRNA, MessengerConceptsSchmidtea mediterraneaAdvent of next-generation sequencing technologiesNext-generation sequencing technologiesGene expressionTissue-specific expression patternsMiRNA mediated gene regulationGenome-wide scaleGenome-wide analysisPoly(A) sitePosttranscriptional gene expressionRegulate posttranscriptional gene expressionGene annotationInternal exonsPolyadenylated transcriptsTranscript isoformsPolyadenylation eventsDegradome sequencingProtein domainsSequencing technologiesPre-mRNAGene regulationCoding sequenceIdeal model systemStem cell functionFreshwater planarians
2013
miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease
Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P. miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 10765-10770. PMID: 23759744, PMCID: PMC3696812, DOI: 10.1073/pnas.1301693110.Peer-Reviewed Original ResearchConceptsMiRNA clusterKidney cyst growthPolycystic kidney diseasePosttranscriptional gene expressionCyst growthOncogenic miRNA clusterShort noncoding RNAsKidney-specific inactivationKidney cyst formationDysregulated miRNA expressionPosttranscriptional repressionNoncoding RNAsHyperproliferative epithelial cellsGene dosageGene expressionHepatocyte nuclear factor-1βGenes PKD1Common genetic causeMiRNA expressionMouse modelFluid-filled cystsMiRNAsKidney diseaseTransgenic overexpressionKidney cysts
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