1999
Increased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors
Zoli M, Picciotto M, Ferrari R, Cocchi D, Changeux J. Increased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors. The EMBO Journal 1999, 18: 1235-1244. PMID: 10064590, PMCID: PMC1171214, DOI: 10.1093/emboj/18.5.1235.Peer-Reviewed Original ResearchConceptsHigh-affinity nicotine receptorsSpatial learningHippocampal pyramidal neuronsRegion-specific alterationsSerum corticosterone levelsPossible animal modelNicotinic acetylcholine receptorsPyramidal neuronsNeuronal survivalNicotine receptorsCholinergic systemEndocrine parametersControl animalsIncreased neurodegenerationAnimal modelsCorticosterone levelsAcetylcholine receptorsAlzheimer's diseaseDegenerative processCortical regionsMorris mazeCognitive deficitsMutant miceMiceBeta2 subunit
1996
Effects of serotonergic agents on food-restriction-induced hyperactivity
Altemus M, Glowa J, Galliven E, Leong Y, Murphy D. Effects of serotonergic agents on food-restriction-induced hyperactivity. Pharmacology Biochemistry And Behavior 1996, 53: 123-131. PMID: 8848441, DOI: 10.1016/0091-3057(95)02003-9.Peer-Reviewed Original ResearchConceptsSaline-treated ratsObsessive-compulsive disorderReuptake inhibitorsSerotonin selective reuptake inhibitorsSelective monoamine reuptake inhibitorsSelective reuptake inhibitorsChronic fluoxetine treatmentMonoamine reuptake inhibitorsTryptophan hydroxylase inhibitorCentral serotonergic activityPossible animal modelOCD symptomsFluoxetine treatmentChronic treatmentPharmacological treatmentSerotonergic agentsSerotonergic neurotransmissionSerotonergic activityFood restrictionHydroxylase inhibitorAnimal modelsRunning wheelRatsParachlorophenylalanineAdditional group
1993
Attenuation of food-restriction-induced running by chronic fluoxetine treatment.
Altemus M, Glowa J, Murphy D. Attenuation of food-restriction-induced running by chronic fluoxetine treatment. Psychopharmacology Bulletin 1993, 29: 397-400. PMID: 8121967.Peer-Reviewed Original ResearchConceptsSaline-treated controlsObsessive-compulsive disorderAnimal modelsRunning wheelChronic fluoxetine treatmentPossible animal modelValid animal modelLife-threatening proportionsOCD symptomsAssociated anorexiaFluoxetine treatmentFood restrictionBody weightRatsAntidepressantsWeight lossSignificant attenuationCompulsive runningProgressive increaseAnorexiaFluoxetineDaily accessSymptomsWeeksTreatment
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply