2014
APUM23, a PUF family protein, functions in leaf development and organ polarity in Arabidopsis
Huang T, Kerstetter RA, Irish VF. APUM23, a PUF family protein, functions in leaf development and organ polarity in Arabidopsis. Journal Of Experimental Botany 2014, 65: 1181-1191. PMID: 24449383, PMCID: PMC3935572, DOI: 10.1093/jxb/ert478.Peer-Reviewed Original ResearchConceptsPlant developmentLeaf developmentArabidopsis leaf developmentLeaf polarity genesPUF family proteinsPre-rRNA processingNormal biological functionsAbaxial identityGARP familyKANADI genesOrgan polarityDivision-competent cellsLeaf morphogenesisAbaxial polarityPolarity genesPuf genesPolarity mutantsDomain proteinsGene familyKan mutantFamily proteinsAPUM23Polarity formationProper differentiationBiological functions
1999
8 Somitogenesis in Zebrafish
Holley S, Nüsslein-Volhard C. 8 Somitogenesis in Zebrafish. Current Topics In Developmental Biology 1999, 47: 247-277. PMID: 10595307, DOI: 10.1016/s0070-2153(08)60727-9.Peer-Reviewed Original ResearchConceptsSomite segmentationSegment polarity genesSpecific muscle typesExtension of axonsPolarity genesNotochord formationDanio rerioSomite developmentGenetic analysisMedial somiteMutantsSomitesGenesEmbryological studiesPrimary motoneuronsSomitogenesisSlow muscle fibersZebrafishNotochordMuscle typesDevelopment of motoneuronsDifferentiationMorphological transitionDrosophilaRerio
1998
Zebrafish segmentation and pair‐rule patterning
van Eeden F, Holley S, Haffter P, Nüsslein‐Volhard C. Zebrafish segmentation and pair‐rule patterning. Genesis 1998, 23: 65-76. PMID: 9706695, DOI: 10.1002/(sici)1520-6408(1998)23:1<65::aid-dvg7>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsDrosophila segment polarity geneSegment polarity genesPair-rule patterningParaxial mesodermZebrafish homologueSomite boundariesPolarity genesPair-rule gene hairyPair-rule genesPair-rule phenotypeWild-type embryosGroup of genesGroup of mutantsGenetic screenVertebrate embryosDouble mutantSomite formationZebrafish segmentationHairy phenotypeMutantsMesodermSonic hedgehogGenesHomologuesHER1 expression
1996
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
Gailani M, Ståhle-Bäckdahl M, Leffell D, Glyn M, Zaphiropoulos P, Undén A, Dean M, Brash D, Bale A, Toftgård R. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nature Genetics 1996, 14: 78-81. PMID: 8782823, DOI: 10.1038/ng0996-78.Peer-Reviewed Original ResearchConceptsSporadic basal cell carcinomasSingle-strand conformational polymorphismTumor suppressorDrosophila segment polarity geneSegment polarity genesHedgehog target genesPolarity genesDrosophila mutantsStrong homologyHuman homologueTarget genesMutational inactivationMutant transcriptsStrand conformational polymorphismNorthern blotSSCP variantsGenesNegative feedback mechanismSitu hybridizationConformational polymorphismNevoid basal cell carcinoma syndromeSuppressorAllelic lossInactivationMutationsMutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Hahn H, Wicking C, Zaphiropoulos P, Gailani M, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden A, Gillies S, Negus K, Smyth I, Pressman C, Leffell D, Gerrard B, Goldstein A, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale A. Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome. Cell 1996, 85: 841-851. PMID: 8681379, DOI: 10.1016/s0092-8674(00)81268-4.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsBasal Cell Nevus SyndromeBase SequenceChromosome MappingChromosomes, Human, Pair 9Cloning, MolecularDNA, ComplementaryDrosophilaDrosophila ProteinsExonsFemaleGene DeletionGene ExpressionGenes, Tumor SuppressorHumansIn Vitro TechniquesInsect HormonesIntronsMembrane ProteinsMolecular Sequence DataMutationPedigreeReceptors, Cell SurfaceSequence Homology, Nucleic AcidConceptsDrosophila segment polarity geneSegment polarity genesCertain cell typesDevelopmental abnormalitiesPolarity genesHuman homologStrong homologySporadic basal cell carcinomasHuman sequenceCosmid contigTumor suppressorLoss of heterozygosityCell typesGenesPatched geneChromosome 9q22.3Complete lossFunction contributesNevoid basal cell carcinoma syndromeMutation analysisBasal cell carcinoma syndromeAutosomal dominant disorderNBCCS patientsDrosophilaDominant disorderA Mammalian patched Homolog Is Expressed in Target Tissues of sonic hedgehog and Maps to a Region Associated with Developmental Abnormalities (∗)
Hahn H, Christiansen J, Wicking C, Zaphiropoulos P, Chidambaram A, Gerrard B, Vorechovsky I, Bale A, Toftgard R, Dean M, Wainwright B. A Mammalian patched Homolog Is Expressed in Target Tissues of sonic hedgehog and Maps to a Region Associated with Developmental Abnormalities (∗). Journal Of Biological Chemistry 1996, 271: 12125-12128. PMID: 8647801, DOI: 10.1074/jbc.271.21.12125.Peer-Reviewed Original ResearchConceptsLimb budSonic hedgehogSegment polarity genesIntegral membrane proteinsVentral neural tubePolarity genesHydropathy analysisPatched proteinCorrect patterningPutative proteinImaginal discsMembrane proteinsDrosophila hedgehogHuman PatchedCDNA sequencePosterior ectodermMurine homologPatched expressionMouse embryosClose functional relationshipNeural tubeLarval segmentsRegion AssociatedAmino acidsHedgehog
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