2022
Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum
Mitchel K, Bergmann JM, Brent AE, Finkelstein TM, Schindler KA, Holzman MA, Jeannotte L, Mansfield JH. Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum. Frontiers In Cell And Developmental Biology 2022, 10: 806545. PMID: 35557949, PMCID: PMC9086245, DOI: 10.3389/fcell.2022.806545.Peer-Reviewed Original ResearchLateral somitic frontierLateral plate mesodermSkeletal patterningTissue-specific contributionsPlate mesodermEmbryonic precursorsGenetic controlProper developmentHOXA5 expressionEmbryonic sourcesRegulate DevelopmentSkeletal phenotypeConditional deletionEmbryological informationMultiple rolesMesodermSkeletal systemHoxSomitesTheriansPrimordiaAdditive roleRegulatorDeletionMost aspects
2018
HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system
Holzman MA, Bergmann JM, Feldman M, Landry-Truchon K, Jeannotte L, Mansfield JH. HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system. The International Journal Of Developmental Biology 2018, 62: 785-796. PMID: 30604848, PMCID: PMC8783609, DOI: 10.1387/ijdb.180214jm.Peer-Reviewed Original ResearchConceptsLateral plate mesodermHOXA5 expressionSkeletal patterningPlate mesodermNon-cell autonomous functionCell-autonomous roleProtein expressionSatellite cell lineageLineage restrictionGenetic lineagesEmbryonic cellsCell lineagesLateral sclerotomeTissue specificitySomite stageSkeletal developmentLineagesAutonomous roleDirect roleMusculoskeletal morphologyTissue typesMesodermHOXA5SomitesAutonomous functions
2016
A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis
McMillen P, Chatti V, Jülich D, Holley SA. A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis. Current Biology 2016, 26: 542-549. PMID: 26853361, PMCID: PMC4822709, DOI: 10.1016/j.cub.2015.12.055.Peer-Reviewed Original ResearchConceptsECM assemblyGenetic mosaicsPosterior somitesDifferential cadherin expressionExtracellular matrixCell-ECM adhesionFN matrix assemblyBoundary formationVertebrate gastrulationSomite boundariesSomite morphogenesisCytoskeletal contractilityParaxial mesodermEmbryonic precursorsCDH activityMatrix assemblyCadherin expressionCDH2SomitesTissue boundariesIntegrin α5SomitogenesisCell sortingCell aggregatesAssembly
2000
Control of her1 expression during zebrafish somitogenesis by a Delta-dependent oscillator and an independent wave-front activity
Holley S, Geisler R, Nüsslein-Volhard C. Control of her1 expression during zebrafish somitogenesis by a Delta-dependent oscillator and an independent wave-front activity. Genes & Development 2000, 14: 1678-1690. PMID: 10887161, PMCID: PMC316735, DOI: 10.1101/gad.14.13.1678.Peer-Reviewed Original ResearchConceptsAnterior presomitic mesodermPresomitic mesodermGene expressionNotch pathwayHER1 expressionZebrafish genesZebrafish somitogenesisEmbryos mutantSomite morphogenesisMolecular clockExpression patternsExpression de novoExpression oscillatesNotch ligandsPathway upstreamSomitogenesisBorder formationConsecutive somitesDe novoSomitesExpressionWave-front modelPathwayClockHER1
1999
8 Somitogenesis in Zebrafish
Holley S, Nüsslein-Volhard C. 8 Somitogenesis in Zebrafish. Current Topics In Developmental Biology 1999, 47: 247-277. PMID: 10595307, DOI: 10.1016/s0070-2153(08)60727-9.Peer-Reviewed Original ResearchConceptsSomite segmentationSegment polarity genesSpecific muscle typesExtension of axonsPolarity genesNotochord formationDanio rerioSomite developmentGenetic analysisMedial somiteMutantsSomitesGenesEmbryological studiesPrimary motoneuronsSomitogenesisSlow muscle fibersZebrafishNotochordMuscle typesDevelopment of motoneuronsDifferentiationMorphological transitionDrosophilaRerio
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