2022
Emerging Concepts in Defective Macrophage Phagocytosis in Cystic Fibrosis
Jaganathan D, Bruscia EM, Kopp BT. Emerging Concepts in Defective Macrophage Phagocytosis in Cystic Fibrosis. International Journal Of Molecular Sciences 2022, 23: 7750. PMID: 35887098, PMCID: PMC9319215, DOI: 10.3390/ijms23147750.Peer-Reviewed Original ResearchConceptsPhagosome formationCystic fibrosis transmembrane conductance regulator (CFTR) geneTransmembrane conductance regulator geneInnate immunityTissue homeostasisRegulator geneMutant CFTRCF macrophagesCystic fibrosisPhagocytic mechanismsPathogenic microbesAdaptive immune systemDefective macrophage phagocytosisCFTRCurrent understandingTherapeutic developmentCentral roleMacrophage phagocytosisCFTR modulatorsPhagocytic cellsPhagocytosisNew therapeutic developmentsMacrophages contributesLung functionChronic inflammation
2021
Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time
Prakash P, Jethava K, Korte N, Izquierdo P, Favuzzi E, Rose I, Guttenplan K, Manchanda P, Dutta S, Rochet J, Fishell G, Liddelow S, Attwell D, Chopra G. Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time. Chemical Science 2021, 12: 10901-10918. PMID: 34476070, PMCID: PMC8372545, DOI: 10.1039/d1sc03486c.Peer-Reviewed Original ResearchAmyloid-bAlzheimer's diseaseStages of ADOrganelles of cellsRegulating brain functionPhagocytic mechanismsRemoved ABGlial cellsAcidic organellesCell lysosomesGreen fluorescenceExtracellular spaceImpaired phagocytic functionWorsened disease outcomeLive animalsPhagocytosisCellsPhagocytic functionNon-fluorescentLysosomesEnzymePhysiological pH.AlzheimerDisease outcomeMechanism
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