2021
Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time
Prakash P, Jethava K, Korte N, Izquierdo P, Favuzzi E, Rose I, Guttenplan K, Manchanda P, Dutta S, Rochet J, Fishell G, Liddelow S, Attwell D, Chopra G. Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time. Chemical Science 2021, 12: 10901-10918. PMID: 34476070, PMCID: PMC8372545, DOI: 10.1039/d1sc03486c.Peer-Reviewed Original ResearchAmyloid-bAlzheimer's diseaseStages of ADOrganelles of cellsRegulating brain functionPhagocytic mechanismsRemoved ABGlial cellsAcidic organellesCell lysosomesGreen fluorescenceExtracellular spaceImpaired phagocytic functionWorsened disease outcomeLive animalsPhagocytosisCellsPhagocytic functionNon-fluorescentLysosomesEnzymePhysiological pH.AlzheimerDisease outcomeMechanism
1997
Identification of a Vesicular Pool of Calcium Channels in the Bag Cell Neurons of Aplysia californica
White B, Kaczmarek L. Identification of a Vesicular Pool of Calcium Channels in the Bag Cell Neurons of Aplysia californica. Journal Of Neuroscience 1997, 17: 1582-1595. PMID: 9030618, PMCID: PMC6573390, DOI: 10.1523/jneurosci.17-05-01582.1997.Peer-Reviewed Original ResearchConceptsBag cell neuronsCalcium channel alpha1 subunitAplysia nervous systemProtein kinase CCell neuronsAplysia californicaBag cell clustersCalcium channelsChannel alpha1 subunitCell clustersVesicular channelsMembrane proteinsReverse-transcribed RNAVesicular localizationPlasma membraneEgg-laying hormoneMolecular mechanismsSubcellular distributionKinase CLysoTracker RedDense-core vesiclesAcidic organellesGrowth conesCalcium channel subtypesCalcium current modulation
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