2018
Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp
Mis MA, Yang Y, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG. Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp. Journal Of Neuroscience 2018, 39: 382-392. PMID: 30459225, PMCID: PMC6335750, DOI: 10.1523/jneurosci.2433-18.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdultChildChronic PainErythromelalgiaExcitatory Postsynaptic PotentialsExomeFemaleGanglia, SpinalHumansImmunohistochemistryIndividualityInduced Pluripotent Stem CellsKCNQ Potassium ChannelsMaleMembrane PotentialsNAV1.7 Voltage-Gated Sodium ChannelPain MeasurementPatch-Clamp TechniquesResilience, PsychologicalSensory Receptor CellsConceptsWhole-exome sequencingPeripheral sensory neuronsSensory neuronsSpecific gene variantsGene variantsPluripotent stem cell-derived sensory neuronsInterindividual differencesDorsal root ganglion neuronsExome sequencingDifferent pain profilesDRG neuron excitabilityDynamic clampPeripheral nervous systemStem cellsPain ProfilePluripotent stem cellsChronic painPeripheral mechanismsGanglion neuronsNeuron excitabilityPainNervous systemHuman genetic modelsNeuronsDifferent gene variantsEffect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice
Bagdas D, Meade J, Alkhlaif Y, Muldoon P, Carroll F, Damaj M. Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice. European Journal Of Pain 2018, 22: 1419-1427. PMID: 29633429, PMCID: PMC6179949, DOI: 10.1002/ejp.1231.Peer-Reviewed Original ResearchEffects of nicotineVisceral painΑ7 nAChRsPlace aversionIntraperitoneal acetic acid administrationAcetic acid administrationAllosteric modulationΑ7-nAChR activationDose-dependent reductionNAChR agonist nicotineNeurobiology of painDose-dependent mannerAntinociceptive effectAcid administrationPeripheral mechanismsAntinociceptive propertiesNAChR activationNicotine effectsNicotinic antagonistsNovel analgesicsSystemic administrationReceptor modulatorsAgonist nicotineNAChR agonistsPain
2017
Cannabis in fat: high hopes to treat obesity
Hawkins MN, Horvath TL. Cannabis in fat: high hopes to treat obesity. Journal Of Clinical Investigation 2017, 127: 3918-3920. PMID: 29035279, PMCID: PMC5663345, DOI: 10.1172/jci97042.Peer-Reviewed Original ResearchConceptsCannabinoid receptor type 1Body weightNovel peripheral targetsReduced body weightSystemic metabolic changesAdipocyte-specific deletionReceptor type 1Sympathetic toneTotal adiposityCNS effectsPeripheral mechanismsSystemic metabolismPeripheral targetsAdipocyte physiologyAdipose tissueType 1Metabolic changesMetabolic profileEnergy metabolismMetabolismAdiposityObesityCausal relationshipMiceMacrophages
2016
SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons
Han Q, Kim YH, Wang X, Liu D, Zhang ZJ, Bey AL, Lay M, Chang W, Berta T, Zhang Y, Jiang YH, Ji RR. SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. Neuron 2016, 92: 1279-1293. PMID: 27916453, PMCID: PMC5182147, DOI: 10.1016/j.neuron.2016.11.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBlotting, WesternCapsaicinGanglia, SpinalHumansHyperalgesiaImmunohistochemistryInflammationMiceMice, KnockoutMicrofilament ProteinsNAV1.8 Voltage-Gated Sodium ChannelNerve Tissue ProteinsNeuralgiaPainPatch-Clamp TechniquesPresynaptic TerminalsReverse Transcriptase Polymerase Chain ReactionSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation ChannelsConceptsHeat hyperalgesiaSensory neuronsDRG neuronsMouse dorsal root ganglion sensory neuronsDorsal root ganglion sensory neuronsCapsaicin-induced spontaneous painAbnormal pain sensitivityHuman DRG neuronsPrimary sensory neuronsAutism spectrum disorderSpinal cord neuronsSpontaneous painTRPV1 signalingNeuropathic painPain sensitivityPeripheral mechanismsCord neuronsSHANK3 haploinsufficiencyTRPV1 functionPresynaptic terminalsSynaptic currentsPain deficitsSHANK3 deficiencyInward currentsSHANK3 expression
2014
Reproductive Hormone Influences on Thermoregulation in Women
Charkoudian N, Stachenfeld N. Reproductive Hormone Influences on Thermoregulation in Women. Comprehensive Physiology 2014, 4: 793-804. DOI: 10.1002/j.2040-4603.2014.tb00558.x.Peer-Reviewed Original ResearchReproductive hormonesHormone exposureMale reproductive hormonesStudy of reproductive hormonesPeripheral thermal informationPeripheral mechanismsAnterior hypothalamusPreoptic areaBody temperatureHormonal influencesPromote vasodilationHormoneYoung womenControl thermoregulationAndrogenEstrogenThermoregulatory responsesWomenThermoregulatory controlMechanisms of thermoregulatory controlLow body temperatureCurrent knowledgeReproductive Hormone Influences on Thermoregulation in Women
Charkoudian N, Stachenfeld NS. Reproductive Hormone Influences on Thermoregulation in Women. 2014, 4: 793-804. PMID: 24715568, DOI: 10.1002/cphy.c130029.ChaptersConceptsReproductive hormonesHormone exposurePeripheral thermal informationReproductive hormone effectsMale reproductive hormonesBody temperatureThermoregulatory responsesProgesterone/progestinsPeripheral mechanismsAnterior hypothalamusPreoptic areaHormone influenceHormone effectsLow body temperatureBody heatingYoung womenThermoregulatory controlEnvironmental exposuresWomenHormoneMajor quantitative differencesProgestinsAndrogensEstrogenPhysiological thermoregulatory responses
2012
Ghrelin Regulation of Learning, Memory, and Neurodegeneration
Horvath T. Ghrelin Regulation of Learning, Memory, and Neurodegeneration. Contemporary Endocrinology 2012, 171-180. DOI: 10.1007/978-1-61779-903-7_9.Peer-Reviewed Original ResearchLate-onset chronic diseasesChronic diseasesGut-derived hormonesCause of morbidityChronic disease developmentGhrelin regulationGhrelin actionPeripheral mechanismsBrain healthTissue malignancyCardiovascular disordersParkinson's diseaseCalorie restrictionBrain functionDiseaseProlongs longevityEpigenetic vulnerabilityFinancial burdenGhrelinCellular energy metabolismDisease developmentEnergy metabolismIntegrative physiologyTissueHealth
2011
Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism
Diano S, Horvath TL. Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. Trends In Molecular Medicine 2011, 18: 52-58. PMID: 21917523, DOI: 10.1016/j.molmed.2011.08.003.Peer-Reviewed Original ResearchConceptsProtein 2Lipid metabolismExcess of nutrientsHypothalamic neuronal circuitsNutrient availabilityPeripheral tissue functionsPhysiological functionsMetabolism regulationChronic diseasesMetabolism-related chronic diseasesTissue functionFuture therapeutic strategiesPathological processesPeripheral mechanismsLipid levelsNeuronal circuitsTherapeutic strategiesMetabolismImpairs healthMitochondriaDiseaseUCP2GlucoseRegulationNutrients
2008
Ghrelin: an orexigenic signal from the stomach
Horvath T. Ghrelin: an orexigenic signal from the stomach. 2008, 266-284. DOI: 10.1017/cbo9780511541643.010.Peer-Reviewed Original ResearchEffects of ghrelinGrowth hormone secretagoguesFood intakeGrowth hormoneGrowth hormone secretagogue receptorDiscovery of ghrelinAmino acid peptide hormoneAnorectic hormonesOrexigenic signalsGhrelin actionPeripheral mechanismsSecretagogue receptorMetabolic effectsHormone secretagoguesBody fatGhrelinPeripheral signalsEndogenous ligandStimulatory effectEnergy expenditurePeptide hormonesCell proliferationIntakeHormoneHormonal regulation
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