2015
Sex hormone effects on autonomic mechanisms of thermoregulation in humans
Charkoudian N, Stachenfeld N. Sex hormone effects on autonomic mechanisms of thermoregulation in humans. Autonomic Neuroscience 2015, 196: 75-80. PMID: 26674572, DOI: 10.1016/j.autneu.2015.11.004.ChaptersConceptsAutonomic mechanismsReproductive hormonesBody temperatureCentral autonomic nucleusHeat dissipation responsePolycystic ovary syndromeFemale reproductive hormonesPeripheral blood vesselsInfluence of progesteroneSkin blood flowAutonomic nucleiOvary syndromePeripheral effectsMenstrual cycleHormone levelsBlood flowHormone effectsLow body temperatureBlood vesselsEstrogenHigh body temperatureRecent evidenceMenopauseProgesteroneThermoregulatory responsesNeuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation
Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1607-1612. PMID: 25605929, PMCID: PMC4321293, DOI: 10.1073/pnas.1421419112.Peer-Reviewed Original ResearchConceptsSummer active stateNervous tissue functionPalmitate-induced uncouplingDifferential transcriptomicsMolecular mechanismsHibernating mammalsBrown adipose tissueBody temperatureProtein 1Ground squirrelsBiochemical analysisTorpid squirrelsHibernation seasonTissue functionActive stateUCP1 expressionHigh expressionHibernationPharmacologic analysisThermogenic proteinsAdipose tissueBrain temperatureLow body temperatureNervous systemPhysiologic phenotype
2014
Reproductive Hormone Influences on Thermoregulation in Women
Charkoudian N, Stachenfeld N. Reproductive Hormone Influences on Thermoregulation in Women. Comprehensive Physiology 2014, 4: 793-804. DOI: 10.1002/j.2040-4603.2014.tb00558.x.Peer-Reviewed Original ResearchReproductive hormonesHormone exposureMale reproductive hormonesStudy of reproductive hormonesPeripheral thermal informationPeripheral mechanismsAnterior hypothalamusPreoptic areaBody temperatureHormonal influencesPromote vasodilationHormoneYoung womenControl thermoregulationAndrogenEstrogenThermoregulatory responsesWomenThermoregulatory controlMechanisms of thermoregulatory controlLow body temperatureCurrent knowledgeReproductive Hormone Influences on Thermoregulation in Women
Charkoudian N, Stachenfeld NS. Reproductive Hormone Influences on Thermoregulation in Women. 2014, 4: 793-804. PMID: 24715568, DOI: 10.1002/cphy.c130029.ChaptersConceptsReproductive hormonesHormone exposurePeripheral thermal informationReproductive hormone effectsMale reproductive hormonesBody temperatureThermoregulatory responsesProgesterone/progestinsPeripheral mechanismsAnterior hypothalamusPreoptic areaHormone influenceHormone effectsLow body temperatureBody heatingYoung womenThermoregulatory controlEnvironmental exposuresWomenHormoneMajor quantitative differencesProgestinsAndrogensEstrogenPhysiological thermoregulatory responses
2013
A protocol-driven approach to early extubation after heart surgery
Fitch Z, Debesa O, Ohkuma R, Duquaine D, Steppan J, Schneider E, Whitman G. A protocol-driven approach to early extubation after heart surgery. Journal Of Thoracic And Cardiovascular Surgery 2013, 147: 1344-1350. PMID: 24269120, DOI: 10.1016/j.jtcvs.2013.10.032.Peer-Reviewed Original ResearchConceptsPatient shiveringRisk factorsVentilation timePostoperative mechanical ventilation timeLow body temperatureStandardized protocolMechanical ventilation timeRate of reintubationIndependent risk factorPercent of patientsPeriod 1 patientProtocol-driven approachBody temperatureReintubation rateEarly extubationProlonged ventilationCoronary bypassHeart surgeryReminder sheetsMultidisciplinary committeePatientsLogistic regressionPatient safetyExtubationBaseline practice
2011
Low Body Temperature Does Not Compromise the Treatment Effect of Alteplase
Lees JS, Mishra NK, Saini M, Lyden PD, Shuaib A. Low Body Temperature Does Not Compromise the Treatment Effect of Alteplase. Stroke 2011, 42: 2618-2621. PMID: 21757664, DOI: 10.1161/strokeaha.110.611210.Peer-Reviewed Original ResearchConceptsBaseline body temperatureAcute ischemic strokeRankin Scale scoreIschemic strokeAlteplase treatmentBaseline severityBody temperatureScale scoreVirtual International Stroke Trials ArchiveRankin Scale distributionsBaseline National InstitutesHealth Stroke ScaleIschemic stroke modelTreatment effectsStroke ScaleThrombolytic therapyImproved outcomesTherapeutic effectTreatment responseStroke modelTreatment groupsAlteplaseCochran-MantelLow body temperatureStroke
2005
77 ADMISSION BODY TEMPERATURE AND MORTALITY IN PATIENTS HOSPITALIZED FOR HEART FAILURE
Nallamothu B, Payvar S, Wang Y, Kosiborod M, Foody J, Masoudi F, Havranek E, Casscells S, Krumholz H. 77 ADMISSION BODY TEMPERATURE AND MORTALITY IN PATIENTS HOSPITALIZED FOR HEART FAILURE. Journal Of Investigative Medicine 2005, 53: s400. DOI: 10.2310/6650.2005.00205.76.Peer-Reviewed Original ResearchOne-year mortalityAdmission body temperatureHeart failureWorse survivalBody temperatureLow body temperatureLogistic regressionPatients 65 yearsAdvanced heart failurePATIENTS HOSPITALIZEDHospital deathMultivariate adjustmentPatient subgroupsIndependent associationClinical dataStudy populationPatientsPolynomial logistic regressionCare ProjectMortalityHospitalSurvivalFailureSignificant relationshipHospitalized
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