2024
Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence
Martins F, Rosay T, Rajan A, Carter H, Turocy T, Mejia A, Crawford J, Maresso A, Sperandio V. Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence. Nature Microbiology 2024, 9: 2448-2461. PMID: 38965331, PMCID: PMC11585081, DOI: 10.1038/s41564-024-01747-1.Peer-Reviewed Original ResearchMeSH KeywordsAdenineAnimalsCoculture TechniquesEnterococcus faecalisEnterocytesEnterohemorrhagic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsGastrointestinal MicrobiomeGene Expression Regulation, BacterialHemolysin ProteinsHost-Pathogen InteractionsHumansHypoxanthineMiceType III Secretion SystemsVirulenceVirulence FactorsXanthineConceptsT3SS gene expressionType 3 secretion systemGene expressionAE lesion formationPromote colonization resistanceE. faecalisAdenine biosynthesisEHEC virulenceEffector translocationBacterial geneticsColonization resistanceEnteric pathogensT3SSLesion formationEHECSupplementation experimentsVirulencePathway activationAdenineEnhanced pathogenesisHost responseCo-InfectionExpressionCo-CultureTranscriptome
2022
Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells
Williamson AJ, Jacobson R, van Praagh JB, Gaines S, Koo HY, Lee B, Chan WC, Weichselbaum R, Alverdy JC, Zaborina O, Shogan BD. Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells. Neoplasia 2022, 27: 100787. PMID: 35366466, PMCID: PMC8971311, DOI: 10.1016/j.neo.2022.100787.Peer-Reviewed Original ResearchConceptsE. faecalisTumor progressionCollagenolytic bacteriaPost-surgical recoveryHuman colon cancer specimensMurine colon cancer cell lineEnterococcus faecalisColon cancer developmentColon cancer specimensColon cancer cell linesCancer cell invasionCurative resectionCancer cell linesColon cancer cellsCancer specimensMouse modelIntestinal microbesCT26 cellsCancer developmentTumor developmentCollagenase productionTumor formationCancer cellsInvasive phenotypeCell invasion
2001
Comparative antimicrobial activity of gatifloxacin with ciprofloxacin and beta-lactams against gram-positive bacteria
Bassetti M, Dembry L, Farrel P, Callan D, Andriole V. Comparative antimicrobial activity of gatifloxacin with ciprofloxacin and beta-lactams against gram-positive bacteria. Diagnostic Microbiology And Infectious Disease 2001, 41: 143-148. PMID: 11750168, DOI: 10.1016/s0732-8893(01)00298-x.Peer-Reviewed Original ResearchConceptsAmoxicillin/clavulanic acidPiperacillin/tazobactamClavulanic acidMethicillin-susceptible S. aureusPenicillin-nonsusceptible Streptococcus pneumoniaeMethicillin-sensitive S. epidermidisMethicillin-resistant coagulase-negative staphylococciGram-positive infectionsViridans group streptococciCoagulase-negative staphylococciPromising new fluoroquinoloneActive agentsNew fluoroquinoloneStreptococcal isolatesGroup streptococciVitro antibacterial activityClinical isolatesStreptococcus pneumoniaeComparative antimicrobial activityStaphylococcal isolatesClinical useEnterococcal isolatesImipenemGatifloxacinE. faecalis
1999
Interferon-γ effects on activities of gentamicin and vancomycin against Enterococcus faecalis resistant to the drugs: an in vitro study with human neutrophils
Onyeji C, Nicolau D, Nightingale C, Bow L. Interferon-γ effects on activities of gentamicin and vancomycin against Enterococcus faecalis resistant to the drugs: an in vitro study with human neutrophils. International Journal Of Antimicrobial Agents 1999, 11: 31-37. PMID: 10075275, DOI: 10.1016/s0924-8579(98)00085-5.Peer-Reviewed Original ResearchConceptsIFN-gammaHuman neutrophilsMajor therapeutic challengeMultidrug-resistant E. faecalisAnti-enterococcal activityEffective antimicrobial therapyMultidrug-resistant enterococciActivity of gentamicinPotential underlying mechanismsEnterococcus faecalisTherapeutic troughMaximal growth inhibitionTherapeutic challengeSerum troughReactive oxygen intermediatesAntimicrobial therapyUseful adjunctClinical isolatesActivated secretionNeutrophilsPeak levelsGentamicinVancomycinPeak concentrationE. faecalis
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