2022
Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis
Di Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis. Experimental & Molecular Medicine 2022, 54: 639-652. PMID: 35581352, PMCID: PMC9166813, DOI: 10.1038/s12276-022-00770-8.Peer-Reviewed Original ResearchConceptsHeme oxygenase-1Cystic fibrosisOxygenase-1Myeloid differentiation factor 88Neutrophilic pulmonary inflammationChronic airway infectionDifferentiation factor 88HO-1 levelsDisease mouse modelPseudomonas aeruginosaRecruitment of monocytesResolution of inflammationMonocytes/macrophagesTreatment of CFConditional knockout miceMechanism of actionLung neutrophiliaNeutrophilic inflammationLung inflammationAirway infectionPulmonary diseasePulmonary inflammationFactor 88Lung damageProinflammatory cytokines
2007
VEGF‐induced heme oxygenase‐1 confers cytoprotection from lethal hyperoxia in vivo
Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ. VEGF‐induced heme oxygenase‐1 confers cytoprotection from lethal hyperoxia in vivo. The FASEB Journal 2007, 21: 1422-1432. PMID: 17264168, DOI: 10.1096/fj.06-6661com.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBronchoalveolar Lavage FluidCytoprotectionDisease Models, AnimalDNA PrimersEnzyme InductionHeme Oxygenase (Decyclizing)HumansHyperoxiaIn Situ Nick-End LabelingLipid PeroxidationLungMiceMice, TransgenicRespiratory Distress SyndromeReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingVascular Endothelial Growth Factor AConceptsHyperoxic acute lung injuryVascular endothelial growth factorAcute lung injuryHeme oxygenase-1Lung injuryTransgenic miceVivo modelLung lavage protein concentrationVEGF transgenic miceLavage protein concentrationEndothelial growth factorHO-1 mRNAHO-1 functionEffect of inhibitionShort hairpin RNAProlong survivalDry ratioProtective effectLethal hyperoxiaHyperoxia resultsOxygenase-1Mouse lungTUNEL stainingCytoprotective effectsInjury
2005
Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury
Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury. The Journal Of Immunology 2005, 175: 4834-4838. PMID: 16210584, DOI: 10.4049/jimmunol.175.8.4834.Peer-Reviewed Original ResearchConceptsTLR4-deficient miceLung injuryAntioxidant gene heme oxygenase-1Gene heme oxygenase-1Oxidant lung injuryBcl-2Heme oxygenase-1Life-sustaining measuresPhospho-Akt levelsNovel mechanistic linkRespiratory failureIll patientsLung integrityMurine modelOxygenase-1Oxidant stressProtective roleHost responseInnate immunityInjuryPhospho-AktHyperoxiaConfer susceptibilityMiceMammalian TLR4
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