JBP1 and JBP2 Proteins Are Fe2+/2-Oxoglutarate-dependent Dioxygenases Regulating Hydroxylation of Thymidine Residues in Trypanosome DNA*
Cliffe L, Hirsch G, Wang J, Ekanayake D, Bullard W, Hu M, Wang Y, Sabatini R. JBP1 and JBP2 Proteins Are Fe2+/2-Oxoglutarate-dependent Dioxygenases Regulating Hydroxylation of Thymidine Residues in Trypanosome DNA*. Journal Of Biological Chemistry 2012, 287: 19886-19895. PMID: 22514282, PMCID: PMC3370173, DOI: 10.1074/jbc.m112.341974.Peer-Reviewed Original ResearchConceptsRegulation of gene expressionOxygen-sensitive regulatorTranscription initiationDioxygenase superfamilyHost nichesO(2)-dependent mannerSynthesis in vivoIn vivo analysisJBP1Inhibiting iron bindingThymidine residuesGene expressionFe(2+Trypanosome DNAIron bindingParasite virulenceHydroxylation in vitroOxidative decarboxylationDioxygenaseAbsorption spectraProteinAnaerobic conditionsSpectroscopic signaturesReduced levelsHydroxyl
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