2024
Evolutionary Strategies Enable Systematic and Reliable Uncertainty Quantification: A Proof-of-Concept Pilot Study on Resting-State Functional MRI Language Lateralization
Stember J, Dishner K, Jenabi M, Pasquini L, K Peck K, Saha A, Shah A, O’Malley B, Ilica A, Kelly L, Arevalo-Perez J, Hatzoglou V, Holodny A, Shalu H. Evolutionary Strategies Enable Systematic and Reliable Uncertainty Quantification: A Proof-of-Concept Pilot Study on Resting-State Functional MRI Language Lateralization. Journal Of Imaging Informatics In Medicine 2024, 38: 576-586. PMID: 38980624, PMCID: PMC11810852, DOI: 10.1007/s10278-024-01188-6.Peer-Reviewed Original ResearchOut-of-distributionDeep neuroevolutionArtificial intelligenceOut-of-distribution imagesTrustworthy artificial intelligenceTest set accuracyUncertainty quantificationComputational complexityEffective uncertainty quantificationAleatoric uncertaintyDistribution entropyMedical diagnosisUQ methodsRadiology applicationsClinical workflowOptimal strategyEnablersNeuroevolutionExpert reviewUQ approachEnsembleExpert assessmentIntelligenceMapsModel ensemble
2023
The Value-of-Information and Value-of-Implementation from Clinical Trials of Diagnostic Tests for HIV-Associated Tuberculosis: A Modeling Analysis
Pei P, Fitzmaurice K, Le M, Panella C, Jones M, Pandya A, Horsburgh C, Freedberg K, Weinstein M, Paltiel A, Reddy K. The Value-of-Information and Value-of-Implementation from Clinical Trials of Diagnostic Tests for HIV-Associated Tuberculosis: A Modeling Analysis. MDM Policy & Practice 2023, 8: 23814683231198873. PMID: 37743931, PMCID: PMC10517616, DOI: 10.1177/23814683231198873.Peer-Reviewed Original ResearchIncremental net monetary benefitOptimal decisionsOptimal strategyNet monetary benefitDecision makers' willingnessHealth economic standpointSputum XpertClinical trialsEconomic outcomesHigh VOTMonetary benefitsNew clinical trial evidenceDiagnostic testsHIV-Associated TuberculosisEconomic standpointClinical trial evidenceVOI analysisPublic health decision makingValue of trialsDownstream health outcomesSouth AfricaEvaluation of trialsHealth decision makingWillingnessDecisions
2022
Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks
Dey R, Zhou W, Kiiskinen T, Havulinna A, Elliott A, Karjalainen J, Kurki M, Qin A, Lee S, Palotie A, Neale B, Daly M, Lin X. Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks. Nature Communications 2022, 13: 5437. PMID: 36114182, PMCID: PMC9481565, DOI: 10.1038/s41467-022-32885-x.Peer-Reviewed Original ResearchConceptsAssociation analysisGenetic variants associated with ageLow frequency variantsState-of-the-art optimization strategiesNatural history of complex diseasesPhenome-wide associationFrequency variantsPopulation structureGenetic dataWhite British ancestryElectronic health recordsUK Biobank participantsCensoring ratesSaddlepoint approximationComplex diseasesSimulation studyPhenotypeBiobank participantsHealth recordsUK BiobankBritish ancestryOptimal strategyAncestrySaddlepointRelatedness
2019
Cost-effectiveness of routine and campaign use of typhoid Vi-conjugate vaccine in Gavi-eligible countries: a modelling study
Bilcke J, Antillón M, Pieters Z, Kuylen E, Abboud L, Neuzil KM, Pollard AJ, Paltiel AD, Pitzer VE. Cost-effectiveness of routine and campaign use of typhoid Vi-conjugate vaccine in Gavi-eligible countries: a modelling study. The Lancet Infectious Diseases 2019, 19: 728-739. PMID: 31130329, PMCID: PMC6595249, DOI: 10.1016/s1473-3099(18)30804-1.Peer-Reviewed Original ResearchConceptsGross domestic productWTP valuesCountry's gross domestic productOptimal strategyCountry-specific willingnessAverage net benefitHealth economic evaluationsGAVI-eligible countriesTyphoid ViPay valueDomestic productVaccine priceWTP thresholdEconomic evaluationVaccine-related costsNet benefitMiddle-income countriesGavi supportVaccine AllianceRoutine immunisationHospital admissionCountriesTCV introductionDALYsTransmission dynamic model
2018
Optimization of Prehospital Triage of Patients With Suspected Ischemic Stroke
Ali A, Zachrison K, Eschenfeldt P, Schwamm L, Hur C. Optimization of Prehospital Triage of Patients With Suspected Ischemic Stroke. Stroke 2018, 49: 2532-2535. PMID: 30355100, PMCID: PMC6205725, DOI: 10.1161/strokeaha.118.022041.Peer-Reviewed Original ResearchConceptsMathematical modelMathematical decision modelMultiple parameter setsOptimal strategyProportion of runsModel input parametersParameter setsInput parametersTimeliness performanceTraffic patternsModel predictionsModel sensitivityIterationModelOptimizationPlausible rangeTransport timeRouting algorithmAlgorithmDiffusion in Random Networks
Manshadi V, Misra S, Rodilitz S. Diffusion in Random Networks. 2018, 1-1. DOI: 10.1145/3230654.3230661.Peer-Reviewed Original ResearchAdoption regimesConsumer purchasing decisionsNetwork economics literatureWord of mouthOptimal seeding strategyOptimal strategySpeed of diffusionFirm facesFirm knowledgeMonopolistic settingPurchasing decisionsTarget consumersIndependent Poisson processesPhase of diffusionFirmsProportion of adoptersBass modelAdoption processCompetitive settingContact costsAdoption levelWOMComparative staticsLevel sEmpirical studies
2017
Cost-effectiveness analysis of typhoid conjugate vaccines in five endemic low- and middle-income settings
Antillón M, Bilcke J, Paltiel AD, Pitzer VE. Cost-effectiveness analysis of typhoid conjugate vaccines in five endemic low- and middle-income settings. Vaccine 2017, 35: 3506-3514. PMID: 28527687, PMCID: PMC5462484, DOI: 10.1016/j.vaccine.2017.05.001.Peer-Reviewed Original ResearchConceptsRoutine infant vaccinationCost-effectiveness analysisOptimal strategyHealthcare payer perspectiveVaccine priceOne-time catchMiddle-income countriesIntervention costsPayer perspectiveInfant vaccinationDong ThapRoutine vaccinationMiddle-income settingsTyphoid transmissionRate of hospitalizationNumber of dosesDynamic modelPricesWorld Health OrganizationInvestmentLwakReturnWillingnessTyphoid feverVaccination
2014
Cost-Effectiveness of Angiographic Imaging in Isolated Perimesencephalic Subarachnoid Hemorrhage
Kalra VB, Wu X, Forman HP, Malhotra A. Cost-Effectiveness of Angiographic Imaging in Isolated Perimesencephalic Subarachnoid Hemorrhage. Stroke 2014, 45: 3576-3582. PMID: 25336513, DOI: 10.1161/strokeaha.114.006679.Peer-Reviewed Original ResearchConceptsOptimal strategyNet monetary benefitCost-effectiveness analysisComprehensive cost-effectiveness analysisCost-effective strategyBase case scenarioDistributional variablesMonetary benefitsLife yearsWillingnessBase caseSensitivity analysisMonte Carlo simulationsInitial CTAPayCarlo simulationsPart of followCostStrategiesVariablesBenefitsDecision treeCase scenarioPurpose
2006
Analyzing the Simultaneous Use of Auctions and Posted Prices for Online Selling
Etzion H, Pinker E, Seidmann A. Analyzing the Simultaneous Use of Auctions and Posted Prices for Online Selling. Manufacturing & Service Operations Management 2006, 8: 68-91. DOI: 10.1287/msom.1060.0101.Peer-Reviewed Original ResearchHigh-valuation consumersDual-channel settingDual-channel strategyPosted PricesMarket segmentationMonopolist sellerMultiunit auctionsAuction durationOnline channelOnline sellingConsumer choiceConsumer marketAuctionsPricesSellersIdentical productsDual channelFirmsOptimal choiceRevenueThreshold policyMarketOptimal strategyConsumersSelling
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply