Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks
Dey R, Zhou W, Kiiskinen T, Havulinna A, Elliott A, Karjalainen J, Kurki M, Qin A, Lee S, Palotie A, Neale B, Daly M, Lin X. Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks. Nature Communications 2022, 13: 5437. PMID: 36114182, PMCID: PMC9481565, DOI: 10.1038/s41467-022-32885-x.Peer-Reviewed Original ResearchConceptsAssociation analysisGenetic variants associated with ageLow frequency variantsState-of-the-art optimization strategiesNatural history of complex diseasesPhenome-wide associationFrequency variantsPopulation structureGenetic dataWhite British ancestryElectronic health recordsUK Biobank participantsCensoring ratesSaddlepoint approximationComplex diseasesSimulation studyPhenotypeBiobank participantsHealth recordsUK BiobankBritish ancestryOptimal strategyAncestrySaddlepointRelatedness
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