Recurrent, truncating Sox9 mutations are associated with sox9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma
Javier B, Yaeger R, Wang L, Sanchez-Vega F, Zehir A, Middha S, Sadowska J, Vakiani E, Shia J, Klimstra D, Ladanyi M, Iacobuzio-Donahue C, Hechtman J. Recurrent, truncating Sox9 mutations are associated with sox9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma. Oncotarget 2016, 7: 50875-50882. PMID: 27248473, PMCID: PMC5239443, DOI: 10.18632/oncotarget.9682.Peer-Reviewed Original ResearchConceptsSOX9 mutationsColorectal carcinomaWild typeAllele-specific copy numberNext generation sequencing dataGeneration sequencing dataProtein expressionAdvanced colorectal carcinomaColorectal carcinoma patientsWild type statusSequence dataSOX9 protein expressionTruncation mutantsAberrant splicingTranscription factor SOX9Protein stabilityOncoscan arrayTruncating mutationsCopy numberMutantsWT-TP53WT proteinMSK-IMPACTKRAS mutationsMolecular subtypes
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