2017
Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival
Ptashkin R, Pagan C, Yaeger R, Middha S, Shia J, O'Rourke K, Berger M, Wang L, Cimera R, Wang J, Klimstra D, Saltz L, Ladanyi M, Zehir A, Hechtman J. Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival. Molecular Cancer Research 2017, 15: 708-713. PMID: 28184012, PMCID: PMC5588907, DOI: 10.1158/1541-7786.mcr-16-0352.Peer-Reviewed Original ResearchConceptsMSK-IMPACTOverall survivalColorectal carcinomaLeft-sided colon cancerHigh-resolution microarraysAdvanced colorectal carcinomaColorectal carcinoma patientsWild-type KRASGenome copy numberNext-generation sequencingColorectal cancer patientsCancer Genome AtlasPrimary tumorCarcinoma patientsMutant TP53Clinical featuresCopy numberRAS/RAF mutationsColon cancerCancer patientsMRNA upregulationMultivariate analysisTranscript expressionPatientsMicrosatellite stability
2016
Recurrent, truncating Sox9 mutations are associated with sox9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma
Javier B, Yaeger R, Wang L, Sanchez-Vega F, Zehir A, Middha S, Sadowska J, Vakiani E, Shia J, Klimstra D, Ladanyi M, Iacobuzio-Donahue C, Hechtman J. Recurrent, truncating Sox9 mutations are associated with sox9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma. Oncotarget 2016, 7: 50875-50882. PMID: 27248473, PMCID: PMC5239443, DOI: 10.18632/oncotarget.9682.Peer-Reviewed Original ResearchConceptsSOX9 mutationsColorectal carcinomaWild typeAllele-specific copy numberNext generation sequencing dataGeneration sequencing dataProtein expressionAdvanced colorectal carcinomaColorectal carcinoma patientsWild type statusSequence dataSOX9 protein expressionTruncation mutantsAberrant splicingTranscription factor SOX9Protein stabilityOncoscan arrayTruncating mutationsCopy numberMutantsWT-TP53WT proteinMSK-IMPACTKRAS mutationsMolecular subtypes
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