2025
Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing A, Jeffery E, Church C, Goodell J, Saavedra-Peña R, Saha M, Holtrup B, Voisin M, Alavi N, Floody M, Wang Z, Zapadka T, Garabedian M, Varshney R, Rudolph M, Rodeheffer M. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Reports 2025, 44: 115527. PMID: 40208790, PMCID: PMC12073628, DOI: 10.1016/j.celrep.2025.115527.Peer-Reviewed Original ResearchAdipocyte precursor cellsDietary fatPlasma monounsaturated fatty acidsAssociated with human obesityHuman adipocyte precursor cellsMonounsaturated fatty acidsDietary fat compositionDietary screeningFatty acidsDietary fatty acidsHuman obesityAdipose expansionMetabolic healthObesity epidemicAkt2 signalingLXR activationPrecursor cellsAdipose biologyOleic acidHyperplasiaObesityAdipocyte hyperplasiaDietary oleic acidPhysiological regulationAdipogenesis
2024
Oleic acid differentially affects lipid droplet storage of de novo synthesized lipids in hepatocytes and adipocytes
Castillo H, Shuster S, Tarekegn L, Davis C. Oleic acid differentially affects lipid droplet storage of de novo synthesized lipids in hepatocytes and adipocytes. Chemical Communications 2024, 60: 3138-3141. PMID: 38329230, PMCID: PMC10939124, DOI: 10.1039/d3cc04829b.Peer-Reviewed Original Research
2021
Oleic acid restores suppressive defects in tissue-resident FOXP3 regulatory T cells from patients with multiple sclerosis
Pompura SL, Wagner A, Kitz A, Laperche J, Yosef N, Dominguez-Villar M, Hafler D. Oleic acid restores suppressive defects in tissue-resident FOXP3 regulatory T cells from patients with multiple sclerosis. Journal Of Clinical Investigation 2021, 131 PMID: 33170805, PMCID: PMC7810477, DOI: 10.1172/jci138519.Peer-Reviewed Original ResearchConceptsMultiple sclerosisAdipose tissueFoxp3 regulatory T cellsExpression of Foxp3Regulatory T cellsTreg suppressive functionProinflammatory arachidonic acidHuman adipose tissuePhosphorylation of STAT5Treg homeostasisFatty acidsPeripheral bloodTissue residencyHealthy donorsInflammatory signalsT cellsTregsFree fatty acidsSuppressive functionArachidonic acidPatientsOleic acidOxidative phosphorylationTranscriptomic programsFoxp3
2020
Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway
Li X, Hu X, Pan T, Dong L, Ding L, Wang Z, Song R, Wang X, Wang N, Zhang Y, Wang J, Yang B. Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway. Biomedicine & Pharmacotherapy 2020, 133: 110802. PMID: 33202286, DOI: 10.1016/j.biopha.2020.110802.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsAnthraquinonesBiomarkersDiet, High-FatDisease Models, AnimalFatty LiverHep G2 CellsHepatocytesHumansHyperlipidemiasHypolipidemic AgentsLipidsLiverMaleProprotein Convertase 9RatsRats, Sprague-DawleyReceptors, LDLSignal TransductionSterol Regulatory Element Binding Protein 2ConceptsAdenosine monophosphate-activated protein kinaseSignaling pathwayLipid accumulationOA-treated HepG2 cellsMonophosphate-activated protein kinaseHigh-fat dietHepG2 cellsPhosphorylated adenosine monophosphate-activated protein kinaseHepatic lipid accumulationPotential molecular mechanismsAnthraquinone compoundsCompound CProtein kinaseMolecular mechanismsLipoprotein receptorHepG2 cell modelLipid-lowering effectsOleic acidPathwayCell modelLipidTotal cholesterolHigh-fat diet ratsAccumulationCells
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