2019
Daming capsule, a hypolipidaemic drug, lowers blood lipids by activating the AMPK signalling pathway
Bian Y, Li X, Li X, Ju J, Liang H, Hu X, Dong L, Wang N, Li J, Zhang Y, Yang B. Daming capsule, a hypolipidaemic drug, lowers blood lipids by activating the AMPK signalling pathway. Biomedicine & Pharmacotherapy 2019, 117: 109176. PMID: 31387185, DOI: 10.1016/j.biopha.2019.109176.Peer-Reviewed Original ResearchConceptsHigh-fat dietDaming capsulePhospho-adenosine monophosphate-activated protein kinaseLevels of TCProtein expression levelsBlood lipidsLDL receptorLDL-CRat modelTotal cholesterolOleic acid-treated HepG2 cellsLDL receptor protein expressionCompound CProtein expressionLow-density lipoprotein cholesterolHepG2 cellsLevels of total cholesterolHigh-fat diet rat liverLipoprotein lipaseExpression levelsHigh-fat diet ratsSerum lipid levelsMonophosphate-activated protein kinaseLiver weight/body weight ratioHigh-fat diet feeding
2013
Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing
Park D, Jiang S, Tadie J, Stigler W, Gao Y, Deshane J, Abraham E, Zmijewski J. Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing. Molecular Medicine 2013, 19: 387-398. PMID: 24091934, PMCID: PMC3883969, DOI: 10.2119/molmed.2013.00065.Peer-Reviewed Original ResearchMeSH KeywordsActinsAminoimidazole CarboxamideAMP-Activated Protein KinasesAnimalsBacteremiaChemotaxis, LeukocyteEnzyme ActivationHeterocyclic Compounds, 3-RingHL-60 CellsHumansMaleMetforminMiceMice, Inbred C57BLNeutrophilsPeritonitisPhagocytosisPhosphorylationProtein Kinase InhibitorsPyridinesRibonucleotidesRNA, Small InterferingSignal TransductionSirolimusConceptsAdenosine monophosphate-activated protein kinaseAminoimidazole carboxamide ribonucleotideActivation of adenosine monophosphate-activated protein kinaseTreatment of neutrophilsAdenosine monophosphate-activated protein kinase activationBacterial killingSmall interfering RNA (siRNA)-mediated knockdownBlockade of AMPK activationAdenosine monophosphate-activated protein kinase inhibitor Compound CIkBa degradationMonophosphate-activated protein kinaseInhibitor compound CDownstream signaling eventsLPS/Toll-like receptor 4Inhibition of chemotaxisActin polymerizationAMPK activationAMPK phosphorylationCompound CSignaling eventsProtein kinaseInability of neutrophilsNeutrophil motilityAssociated with severe infectionsInvading microorganisms
2012
Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation
Shugrue C, Alexandre M, de Villalvilla A, Kolodecik TR, Young LH, Gorelick FS, Thrower EC. Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. AJP Gastrointestinal And Liver Physiology 2012, 303: g723-g732. PMID: 22821946, PMCID: PMC3468535, DOI: 10.1152/ajpgi.00082.2012.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAminoimidazole CarboxamideAMP-Activated Protein KinasesAnimalsCells, CulturedCeruletideCyclic AMP-Dependent Protein KinasesEnzyme PrecursorsGene Expression RegulationMaleMetforminOctoxynolPancreasPhosphorylationPyrazolesPyrimidinesRatsRats, Sprague-DawleyRibonucleotidesSodium Dodecyl SulfateConceptsAdenosine monophosphate-activated protein kinaseZymogen activationAMPK activityPancreatic acinar cellsMonophosphate-activated protein kinaseVacuolar ATPase activityAMPK levelsDigestive enzyme zymogensAMPK effectsProtein kinaseProtein kinase levelsE subunitAcinar cellsTime-dependent translocationCompound CCellular modelPancreatitis responsesATPase activityDifferential centrifugationPremature activationChymotrypsin activityActivationInitiating eventSoluble fractionCerulein hyperstimulation
1999
Regulation of myocardial glucose uptake and transport during ischemia and energetic stress
Young L, Russell R, Yin R, Caplan M, Ren J, Bergeron R, Shulman G, Sinusas A. Regulation of myocardial glucose uptake and transport during ischemia and energetic stress. The American Journal Of Cardiology 1999, 83: 25-30. PMID: 10750583, DOI: 10.1016/s0002-9149(99)00253-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEnergetic stressEnergy-generating metabolic pathwaysMonophosphate-activated protein kinaseGlucose uptakeGlucose transport proteinProtein kinaseTransporter translocationTransport proteinsMolecular mechanismsMetabolic pathwaysCardiac glucose uptakeGlucose transporterCellular mechanismsGlucose transportFuel gaugeKinaseTranslocationGlucose entryModerate regional ischemiaSubsequent metabolismGlucose utilization increasesImportant roleUptakeGLUT4Stress
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