Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases
Fioretti F, Testani J, Tio M, Pitt B, Butler J. Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases. Journal Of The American College Of Cardiology 2025, 86: 354-373. PMID: 40738563, DOI: 10.1016/j.jacc.2025.06.012.Peer-Reviewed Original ResearchConceptsMineralocorticoid receptor antagonist therapyMineralocorticoid receptor antagonistsChronic kidney diseaseNonsteroidal mineralocorticoid receptor antagonistAldosterone synthase inhibitorsHeart failureAssociated with progressionExcess aldosteronePartial agonistSynthase inhibitorAssociated with progression of chronic kidney diseaseRenin-angiotensin-aldosterone system inhibitorsRenin-angiotensin-aldosterone system activationProgression of chronic kidney diseaseResistant arterial hypertensionMR-mediated effectsEffects of aldosteroneAssociated with elevationAldosterone levelsNeurohormonal activationProspective trialsReceptor antagonistArterial hypertensionAldosterone productionSystem inhibitors
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