Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse
Lee J, Dieckmann N, Edgar J, Griffiths G, Siegel R. Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse. Immunity Inflammation And Disease 2018, 6: 312-321. PMID: 29642281, PMCID: PMC5946154, DOI: 10.1002/iid3.219.Peer-Reviewed Original ResearchConceptsIntraluminal vesiclesImmune synapseCytolytic granulesImmune synapsesCognate receptor FasType II transmembrane proteinFormation of immune synapsesMembrane-bound FasLNK cellsPerforin-containing granulesIntra-luminal vesiclesReceptor FasFusion proteinTransmembrane proteinsB cellsPlasma membraneFas ligandFasLImmunoelectron microscopyNK cell cytotoxicityHuman NK cellsFASDense-coreVesiclesPerforin/granzyme system
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