Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia
Gu S, Sonkar V, Katare P, Kumar R, Kruger W, Arning E, Bottiglieri T, Lentz S, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. Journal Of The American Heart Association 2020, 9: e013368. PMID: 32067580, PMCID: PMC7070222, DOI: 10.1161/jaha.119.013368.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierCell DeathCells, CulturedCystathionine beta-SynthaseDisease Models, AnimalDisease ProgressionExcitatory Amino Acid AntagonistsHomocysteineHomocystinuriaHyperhomocysteinemiaInfarction, Middle Cerebral ArteryMemantineMice, KnockoutNeuronsNeuroprotective AgentsReceptors, N-Methyl-D-AspartateSeverity of Illness IndexConceptsN-methyl-D-aspartatePlasma total homocysteineBlood-brain barrier disruptionTotal homocysteineBrain barrier disruptionIschemic strokeN-methyl-D-aspartate receptor antagonismBarrier disruptionCerebrovascular injuryN-methyl-D-aspartate receptor antagonistExpression of NR2B subunitN-methyl-D-aspartate receptor subunitsExpression of N-methyl-D-aspartate receptor subunitsN-methyl-D-aspartate receptor antagonist memantineCystathionine beta-synthaseEffects of memantineCerebral infarct sizeTargeted treatment strategiesAcute ischemic strokeBlood-brain barrierReceptor antagonismNR2B subunitReceptor antagonistSevere elevationHomocysteine levels
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