2023
Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults
Reitlo L, Mihailovic J, Stensvold D, Wisløff U, Hyder F, Håberg A. Hippocampal neurochemicals are associated with exercise group and intensity, psychological health, and general cognition in older adults. GeroScience 2023, 45: 1667-1685. PMID: 36626020, PMCID: PMC10400748, DOI: 10.1007/s11357-022-00719-9.Peer-Reviewed Original ResearchConceptsSupervised exercise groupNational physical activity guidelinesPhysical activity guidelinesLower NAA/CrHippocampal bodyNAA/CrActivity guidelinesControl groupExercise groupLower Cho/CrPhysical activity/exerciseOlder adultsGeneration 100 StudyPsychological healthModerate physical activityActivity/exerciseDays/weekPeak oxygen uptakeCho/CrHigher training intensityMagnetic resonance imagingHigh-intensity trainingHippocampal metabolitesNeuronal viabilityHippocampal volume
2014
Concussive brain injury from explosive blast
de Lanerolle NC, Hamid H, Kulas J, Pan JW, Czlapinski R, Rinaldi A, Ling G, Bandak FA, Hetherington HP. Concussive brain injury from explosive blast. Annals Of Clinical And Translational Neurology 2014, 1: 692-702. PMID: 25493283, PMCID: PMC4241796, DOI: 10.1002/acn3.98.Peer-Reviewed Original ResearchMild traumatic brain injuryBlast mild traumatic brain injuryPosttraumatic stress disorderMagnetic resonance spectroscopic imagingN-acetyl aspartateBrain injuryMemory impairmentNAA/ChConcussive brain injuryNAA/CrTraumatic brain injuryVariety of symptomsStudy of veteransLarge animal modelHippocampal injuryNeuronal injuryNeuropsychiatric deficitsRight hippocampusMTBI subjectsPosterior hippocampusAnimal modelsHippocampusInjuryStress disorderCognitive AssessmentCerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection
Young AC, Yiannoutsos CT, Hegde M, Lee E, Peterson J, Walter R, Price RW, Meyerhoff DJ, Spudich S. Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection. Neurology 2014, 83: 1592-1600. PMID: 25261502, PMCID: PMC4223087, DOI: 10.1212/wnl.0000000000000932.Peer-Reviewed Original ResearchConceptsPrimary HIV infectionParietal gray matterInitiation of ARTMI/CrFrontal white matterAntiretroviral therapyGlu/CrCho/CrHIV infectionBasal gangliaWhite matterGray matterN-acetylaspartateT proton magnetic resonance spectroscopyCerebral metabolite changesEarly ART initiationTreatment-naive participantsEarly antiretroviral therapyLevels of glutamateNAA/CrProton magnetic resonance spectroscopyCholine-containing metabolitesMagnetic resonance spectroscopyART initiationHigh-field magnetic resonance spectroscopy
2013
7T MR spectroscopic imaging in the localization of surgical epilepsy
Pan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.Peer-Reviewed Original ResearchConceptsSevere metabolic abnormalitiesLocalization-related epilepsyMR spectroscopic imagingN-acetyl aspartateComplete resectionMetabolic abnormalitiesBetter outcomesMedial temporal lobe epilepsyResection regionTemporal lobe epilepsyNAA/CrSeizure onset zoneSurgical resectionLobe epilepsySurgical approachSeizure localizationMetabolic dysfunctionInternational LeagueSurgical epilepsyGray matterEpilepsyResectionAbnormalitiesMRSI abnormalitiesOutcome prediction
2012
Metabolic networks in epilepsy by MR spectroscopic imaging
Pan JW, Spencer DD, Kuzniecky R, Duckrow RB, Hetherington H, Spencer SS. Metabolic networks in epilepsy by MR spectroscopic imaging. Acta Neurologica Scandinavica 2012, 126: 411-420. PMID: 22574807, PMCID: PMC3600585, DOI: 10.1111/j.1600-0404.2012.01665.x.Peer-Reviewed Original ResearchConceptsMTLE patientsBasal gangliaEpileptic networkMesial temporal lobe epilepsy patientsTemporal lobe epilepsy patientsLimbic seizure propagationBilateral basal gangliaNAA/CrMR spectroscopicIpsilateral insulaSeizure propagationBilateral hippocampusEpilepsy patientsHuman studiesIndependent factorsPatientsNeuronal functionThalamusGangliaEpilepsyInsulaFactor analysisFactorsHippocampusInjury
2009
Intracranial EEG power and metabolism in human epilepsy
Pan JW, Zaveri HP, Spencer DD, Hetherington HP, Spencer SS. Intracranial EEG power and metabolism in human epilepsy. Epilepsy Research 2009, 87: 18-24. PMID: 19699059, PMCID: PMC2783857, DOI: 10.1016/j.eplepsyres.2009.07.006.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyNAA/CrMesial temporal lobeNeocortical epilepsySeizure onset zoneN-acetyl aspartateHigh-frequency activityTemporal lobeOnset zoneFrequency activityMetabolic imagingIntracranial EEG analysisTemporal lobe epilepsyEEG powerQuantitative EEG measuresLobe epilepsySame anatomical regionMTLE groupSeizure localizationHuman epilepsyTissue injuryEpilepsy patientsHuman studiesAbnormal manifestationsEpilepsy
2003
Reduced glutamate neurotransmission in patients with Alzheimer's disease–an in vivo 13C magnetic resonance spectroscopy study
Lin AP, Shic F, Enriquez C, Ross BD. Reduced glutamate neurotransmission in patients with Alzheimer's disease–an in vivo 13C magnetic resonance spectroscopy study. Magnetic Resonance Materials In Physics, Biology And Medicine 2003, 16: 29-42. PMID: 12695884, DOI: 10.1007/s10334-003-0004-x.Peer-Reviewed Original ResearchConceptsN-acetyl aspartateGlutamate neurotransmissionAlzheimer's diseaseCognitive impairmentAD patientsMagnetic resonance spectroscopy measuresPosterior parietal white matterNeuronal tricarboxylic acid cycleCerebral metabolic rateMagnetic resonance spectroscopy studyAge-matched controlsNAA/CrMyo-inositol ratioCognitive impairment characteristicGlucose oxidationMRS measuresNeuronal integrityNeuronal TCA cycleWhite matterGray matterImpairment characteristicPatientsEnrichment of glutamateGlucose ivPilot study
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