2022
Factors associated with progression and mortality among patients undergoing stereotactic radiosurgery for intracranial metastasis: results from a national real-world registry.
Alvi MA, Asher AL, Michalopoulos GD, Grills IS, Warnick RE, McInerney J, Chiang VL, Attia A, Timmerman R, Chang E, Kavanagh BD, Andrews DW, Walter K, Bydon M, Sheehan JP. Factors associated with progression and mortality among patients undergoing stereotactic radiosurgery for intracranial metastasis: results from a national real-world registry. Journal Of Neurosurgery 2022, 137: 985-998. PMID: 35171833, DOI: 10.3171/2021.10.jns211410.Peer-Reviewed Original ResearchMultivariable Cox proportional hazards analysisCox proportional hazards analysisAdministration of immunotherapyProportional hazards analysisStereotactic radiosurgeryIntracranial metastatic lesionsMetastatic lesionsOverall progressionLesion responseInitial stereotactic radiosurgeryMultifraction stereotactic radiosurgeryProgressive intracranial diseaseNeuro-Oncology criteriaOutcomes of patientsReal-world registryResponse Evaluation CriteriaGood local controlIntracranial metastatic diseaseKaplan-Meier analysisCommon primary tumorHazard of progressionLarger lesion sizeSingle-fraction treatmentLesion regressionMedian survival
2021
Can a simplified CT response criteria for vascular involvement in pancreatic adenocarcinoma after neoadjuvant therapy predict survival in patients who achieved subsequent R0 resection?
Guo Y, Czeyda-Pommersheim F, Miccio JA, Mahalingam S, Cecchini M, Pahade J. Can a simplified CT response criteria for vascular involvement in pancreatic adenocarcinoma after neoadjuvant therapy predict survival in patients who achieved subsequent R0 resection? Abdominal Radiology 2021, 46: 5609-5617. PMID: 34557934, DOI: 10.1007/s00261-021-03284-5.Peer-Reviewed Original ResearchConceptsSubsequent R0 resectionOverall survivalR0 resectionNeoadjuvant therapyPancreatic ductal adenocarcinomaImaging responseMultivariable Cox proportional hazards analysisCox proportional hazards analysisPostoperative CA19-9Median overall survivalImproved diseaseProportional hazards analysisKaplan-Meier analysisSimilar diseasesPatient ageVascular involvementClinical stagingMethodsRetrospective analysisPredict SurvivalClinical parametersPDAC patientsCA 19CA19-9Mean ageCancer patientsClinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group
Shimokawa H, Suda A, Takahashi J, Berry C, Camici PG, Crea F, Escaned J, Ford T, Yii E, Kaski JC, Kiyooka T, Mehta PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yasuda S, Beltrame JF, Merz CNB, Group O. Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group. European Heart Journal 2021, 42: 4592-4600. PMID: 34038937, PMCID: PMC8633728, DOI: 10.1093/eurheartj/ehab282.Peer-Reviewed Original ResearchConceptsMajor cardiovascular eventsCoronary artery diseaseMicrovascular anginaPrognosis of patientsInternational Study GroupClinical characteristicsStudy groupPrevious historyMultivariable Cox proportional hazards analysisNon-fatal myocardial infarctionCox proportional hazards analysisSeattle Angina Questionnaire scoresNon-fatal strokeAcute coronary syndromeProspective cohort studyStable angina pectorisProportional hazards analysisImportant health problemComparable prognosisCardiovascular deathCardiovascular eventsCoronary syndromePrimary endpointCohort studyUnstable anginaAutomated digital TIL analysis (ADTA) adds prognostic value to standard assessment of depth and ulceration in primary melanoma
Moore MR, Friesner ID, Rizk EM, Fullerton BT, Mondal M, Trager MH, Mendelson K, Chikeka I, Kurc T, Gupta R, Rohr BR, Robinson EJ, Acs B, Chang R, Kluger H, Taback B, Geskin LJ, Horst B, Gardner K, Niedt G, Celebi JT, Gartrell-Corrado RD, Messina J, Ferringer T, Rimm DL, Saltz J, Wang J, Vanguri R, Saenger YM. Automated digital TIL analysis (ADTA) adds prognostic value to standard assessment of depth and ulceration in primary melanoma. Scientific Reports 2021, 11: 2809. PMID: 33531581, PMCID: PMC7854647, DOI: 10.1038/s41598-021-82305-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsyChemotherapy, AdjuvantClinical Decision-MakingDeep LearningFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedKaplan-Meier EstimateLymphocytes, Tumor-InfiltratingMaleMelanomaMiddle AgedNeoplasm StagingPatient SelectionPrognosisRetrospective StudiesRisk AssessmentROC CurveSkinSkin NeoplasmsYoung AdultConceptsTumor-infiltrating lymphocytesDisease-specific survivalEarly-stage melanomaOpen-source deep learningCutoff valueMultivariable Cox proportional hazards analysisCox proportional hazards analysisDeep learningLow-risk patientsProportional hazards analysisKaplan-Meier analysisAccurate prognostic biomarkersEosin imagesAccuracy of predictionAdjuvant therapyRisk patientsSpecific survivalPrognostic valueValidation cohortReceiver operating curvesTraining cohortTIL analysisClinical trialsPrimary melanomaPrognostic biomarker
2020
Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases
Kurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases. Journal Of Gastrointestinal Oncology 2020, 11: 76-83. PMID: 32175108, PMCID: PMC7052756, DOI: 10.21037/jgo.2020.01.03.Peer-Reviewed Original ResearchLiver-first approachIsolated liver metastasesColon adenocarcinomaLiver metastasesMultivariable Cox proportional hazards analysisCox proportional hazards analysisNational Cancer DatabaseProportional hazards analysisRisk of deathCompletion resectionResection sequenceUpfront chemotherapyExtrahepatic metastasesMedian survivalClinical outcomesHepatic metastasesCAC patientsKaplan-MeierMetastatic tumorsCancer DatabaseColon cancerCAC casesPatientsMetastasisGreater likelihood
2019
Transient ischaemic dilation and post-stress wall motion abnormality increase risk in patients with less than moderate ischaemia: analysis of the REFINE SPECT registry.
Miller RJH, Hu LH, Gransar H, Betancur J, Eisenberg E, Otaki Y, Sharir T, Fish MB, Ruddy TD, Dorbala S, Carli MD, Einstein AJ, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman T, Germano G, Tamarappoo BK, Dey D, Berman DS, Slomka PJ. Transient ischaemic dilation and post-stress wall motion abnormality increase risk in patients with less than moderate ischaemia: analysis of the REFINE SPECT registry. European Heart Journal - Cardiovascular Imaging 2019, 21: 567-575. PMID: 31302679, PMCID: PMC7167750, DOI: 10.1093/ehjci/jez172.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsTransient ischemic dilationWall motion abnormalitiesModerate ischaemiaMyocardial perfusion imagingMild ischaemiaIschemic dilationMultivariable Cox proportional hazards analysisHigh-risk imaging featuresCox proportional hazards analysisTomography myocardial perfusion imagingAdverse cardiovascular eventsHigh-risk featuresGroup of patientsProportional hazards analysisIncremental prognostic utilityTotal perfusion deficitREFINE SPECT registrySingle photon emissionMedian followCardiovascular eventsCardiovascular riskMultivariable analysisPrognostic utilityPerfusion deficits
2017
Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study
Oprea AD, Del Rio JM, Cooter M, Green CL, Karhausen JA, Nailer P, Guinn NR, Podgoreanu MV, Stafford-Smith M, Schroder JN, Fontes ML, Kertai MD. Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study. Journal Canadien D'anesthésie 2017, 65: 46-59. PMID: 29098634, DOI: 10.1007/s12630-017-0991-0.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPostoperative acute kidney injuryCoronary artery bypassPostoperative anemiaDay of surgerySerum hemoglobin concentrationPreoperative anemiaHemoglobin concentrationArtery bypassCABG surgeryKidney injuryGlobal Outcomes (KDIGO) Clinical Practice GuidelineIncidence of AKIMultivariable Cox proportional hazards analysisSingle large academic medical centerCox proportional hazards analysisPostoperative hemoglobin concentrationPostoperative hemoglobin levelsLong-term mortalityTenth postoperative dayProportional hazards analysisRetrospective observational studyLarge academic medical centerClinical practice guidelinesPotential risk factors
2016
Elderly patients undergoing SBRT for inoperable early-stage NSCLC achieve similar outcomes to younger patients
Mancini BR, Park HS, Harder EM, Rutter CE, Corso CD, Decker RH, Husain ZA. Elderly patients undergoing SBRT for inoperable early-stage NSCLC achieve similar outcomes to younger patients. Lung Cancer 2016, 97: 22-27. PMID: 27237023, DOI: 10.1016/j.lungcan.2016.04.011.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerEarly-stage non-small cell lung cancerStereotactic body radiation therapyNon-elderly patientsElderly patientsDistant controlOverall survivalYounger patientsInoperable early-stage non-small cell lung cancerUse of SBRTStage non-small cell lung cancerLocal controlMultivariable Cox proportional hazards analysisCox proportional hazards analysisGrade 5 toxicityNon-elderly cohortProportional hazards analysisCell lung cancerRisk of complicationsRate of efficacyBody radiation therapyLogistic regression analysisLate gradeAcute gradeSurgical resection
2014
Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation
Castleberry AW, Williams JB, Daneshmand MA, Honeycutt E, Shaw LK, Samad Z, Lopes RD, Alexander JH, Mathew JP, Velazquez EJ, Milano CA, Smith PK. Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation. Circulation 2014, 129: 2547-2556. PMID: 24744275, PMCID: PMC4142433, DOI: 10.1161/circulationaha.113.005223.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassDatabases, BibliographicFemaleFollow-Up StudiesHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMyocardial IschemiaMyocardial RevascularizationPercutaneous Coronary InterventionProportional Hazards ModelsRetrospective StudiesRisk FactorsSeverity of Illness IndexStentsConceptsIschemic mitral regurgitationPercutaneous coronary interventionMitral valve repairSignificant coronary artery diseaseSevere ischemic mitral regurgitationCoronary artery diseaseMitral regurgitationCoronary interventionValve repairMedical treatmentArtery diseaseTreatment strategiesLower mortalityMultivariable Cox proportional hazards analysisCox proportional hazards analysisCoronary artery bypassMitral valve surgeryKaplan-Meier methodProportional hazards analysisMitral regurgitation severitySurgical revascularizationArtery bypassValve surgeryOptimal treatmentCABG
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