2012
Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice
Gross ER, Gershon MD, Margolis KG, Gertsberg ZV, Li Z, Cowles RA. Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice. Gastroenterology 2012, 143: 408-417.e2. PMID: 22609381, PMCID: PMC3687781, DOI: 10.1053/j.gastro.2012.05.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCholine O-AcetyltransferaseCholinergic NeuronsEnterochromaffin CellsIntestinal MucosaKetanserinMaleMiceMice, Inbred C57BLMice, KnockoutMuscarinic AntagonistsReceptor, Serotonin, 5-HT2AScopolamineSelective Serotonin Reuptake InhibitorsSerotonergic NeuronsSerotoninSerotonin AntagonistsSerotonin Plasma Membrane Transport ProteinsTryptophan HydroxylaseConceptsSelective serotonin re-uptake inhibitorsSerotonin re-uptake inhibitorsRe-uptake inhibitorsWild-type miceIntestinal mucosaSerotonin re-uptake transporterCholinergic submucosal neuronsIntestinal mucosal epitheliumRe-uptake transporterTryptophan hydroxylase 1Tryptophan hydroxylase 2Submucosal neuronsCholinergic neuronsCholine acetyltransferaseNeuronal serotoninMucosal growthMucosal epitheliumMucosal cellsSERT knockoutEpithelial proliferationAbstractTextMiceHydroxylase 2MucosaNeural precursors
2007
Expression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers
Yoo N, Lee S, Jeong E, Lee J, Soung Y, Nam S, Kim S, Lee J, Lee S. Expression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers. Pathology - Research And Practice 2007, 203: 73-78. PMID: 17207586, DOI: 10.1016/j.prp.2006.11.002.Peer-Reviewed Original ResearchConceptsFas-associated death domainCell death functionP-FADDNo significant associationPhosphorylation of Fas-associated death domainGastric cancerDeath receptor-mediated apoptosisNormal gastric mucosal cellsNuclear expressionReceptor-mediated apoptosisCell cycle regulationNormal gastric cellsTissue microarray approachGlandular epithelial cellsDeath domainGastric mucosal cellsMicroarray approachClinocopathological characteristicsGastric adenocarcinomaGastric carcinomaEpithelial cellsCancer cellsMucosal cellsGastric cellsNormal cells
2006
Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas
Lee J, Jeong E, Soung Y, Nam S, Lee J, Yoo N, Lee S. Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas. Pathology 2006, 38: 312-315. PMID: 16916719, DOI: 10.1080/00313020600820880.Peer-Reviewed Original ResearchConceptsBif-1 expressionBax-interacting factor-1Bif-1Epithelial cellsIntrinsic pathwayIntrinsic pathway of apoptosisGastric carcinomaMalignant gastric epithelial cellsExpression of Bif-1Normal mucosal epithelial cellsNormal gastric mucosal cellsPathway of apoptosisMucosal cellsEvasion of apoptosisTissue microarray approachFactor 1Glandular epithelial cellsNormal mucosal cellsIntensity of immunostainingMucosal epithelial cellsGastric mucosal cellsHallmarks of cancerBax activationGastric epithelial cellsMicroarray approachImmunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas
Lee J, Jeong E, Soung Y, Kim S, Nam S, Kim S, Lee J, Yoo N, Lee S. Immunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas. Pathology - Research And Practice 2006, 202: 497-501. PMID: 16723191, DOI: 10.1016/j.prp.2006.03.004.Peer-Reviewed Original ResearchConceptsApoptosis-inducing factor expressionApoptosis-inducing factorExpression of apoptosis-inducing factorMalignant gastric epithelial cellsExpression patternsGastric tumorigenesisNormal gastric mucosal cellsCaspase-independent apoptosisAdvanced gastric carcinomaDeath of cellsGastric epithelial cellsMitochondrial proteinsOxidoreductase functionGastric carcinomaMucosal cellsImmunohistochemical analysisNormal mucosal cellsParietal cellsGastric parietal cellsTumorigenesisDiffuse-type cancerDepth of invasionEpithelial cellsIntestinal-type cancerGastric mucosal cells
2004
Loss of caspase‐2, ‐6 and ‐7 expression in gastric cancers
YOO N, LEE J, KIM Y, SOUNG Y, KIM S, NAM S, PARK W, LEE J, LEE S. Loss of caspase‐2, ‐6 and ‐7 expression in gastric cancers. Apmis 2004, 112: 330-335. PMID: 15511269, DOI: 10.1111/j.1600-0463.2004.t01-1-apm1120602.x.Peer-Reviewed Original ResearchConceptsLoss of caspase-2Caspase-2Expression of caspase-2Normal gastric mucosal cellsMechanism of gastric cancer developmentApoptotic cell deathGastric cancer cellsCancer developmentHuman cancer developmentMicroarray approachCell deathGastric cancerGastric cancer developmentCancer cellsTissue microarray approachCaspaseSurface mucous cellsNormal gastric mucosaGastric mucosal cellsMucous cellsExpressionCellsGastric carcinomaMucosal cellsGastric mucosa
1980
Mechanism of increased potassium secretion in potassium loading and sodium deprivation
Hayslett J, Myketey N, Binder H, Aronson P. Mechanism of increased potassium secretion in potassium loading and sodium deprivation. American Journal Of Physiology 1980, 239: f378-f382. PMID: 6252786, DOI: 10.1152/ajprenal.1980.239.4.f378.Peer-Reviewed Original ResearchConceptsPlasma membrane-rich fractionMembrane-rich fractionBasolateral cell membraneCell membraneBasolateral membraneColonic cellsEnzyme activityK adaptationNa-K-ATPase activityMembraneColonic mucosal cellsEnzymeCellsMarker enzymesSpecific bindingOuabain-binding sitesAdenylate cyclaseSodium-deprived animalsAnimalsProteinK pumpActivityMucosal cellsATPSites
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