2012
HER2 Expression in Gastric and Gastroesophageal Junction Adenocarcinoma in a US Population
Kunz PL, Mojtahed A, Fisher GA, Ford JM, Chang DT, Balise RR, Bangs CD, Cherry AM, Pai RK. HER2 Expression in Gastric and Gastroesophageal Junction Adenocarcinoma in a US Population. Applied Immunohistochemistry & Molecular Morphology 2012, 20: 13-24. PMID: 21617522, PMCID: PMC6402787, DOI: 10.1097/pai.0b013e31821c821c.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overBreast NeoplasmsEsophageal NeoplasmsFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansImmunohistochemistryIn Situ Hybridization, FluorescenceIncidenceMaleMiddle AgedReceptor, ErbB-2Retrospective StudiesStomach NeoplasmsUnited StatesConceptsGastroesophageal junction cancerHER2-positive adenocarcinomaGastroesophageal junction carcinomaJunction cancerHER2 expressionHER2 statusClinical Oncology/CollegeHER2-positive gastricGastroesophageal junction adenocarcinomaGastric Cancer TrialIntestinal-type adenocarcinomaPrimary tumor siteMembranous staining patternHER2/CEP17 ratioPrimary gastric adenocarcinomaTissue microarray approachASCO/CAPHER2 gene amplificationHER2 protein expressionJunction adenocarcinomaDiffuse adenocarcinomaGastroesophageal junctionPatient survivalTherapeutic optionsIntestinal type
2007
Expression of beclin‐1, an autophagy‐related protein, in gastric and colorectal cancers
AHN C, JEONG E, LEE J, KIM M, KIM S, KIM S, YOO N, LEE S. Expression of beclin‐1, an autophagy‐related protein, in gastric and colorectal cancers. Apmis 2007, 115: 1344-1349. PMID: 18184403, DOI: 10.1111/j.1600-0463.2007.00858.x.Peer-Reviewed Original ResearchConceptsLoss of expressionNo significant associationExpression of Beclin-1Association of beclin-1 expressionGastric cancerNormal mucosal epithelial cellsEpithelial cellsWeak expressionBeclin-1 expressionTissue microarray approachNormal mucosal cellsBreast cancer cellsMucosal epithelial cellsHaploinsufficient tumor suppressorGastric carcinoma tissuesNormal breast cellsGastric epithelial cellsClinocopathological characteristicsTumor suppressor functionBeclin-1Colorectal carcinomaBreast cancerGastric carcinomaColorectal cancerNeo-expressionExpression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers
Yoo N, Lee S, Jeong E, Lee J, Soung Y, Nam S, Kim S, Lee J, Lee S. Expression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers. Pathology - Research And Practice 2007, 203: 73-78. PMID: 17207586, DOI: 10.1016/j.prp.2006.11.002.Peer-Reviewed Original ResearchConceptsFas-associated death domainCell death functionP-FADDNo significant associationPhosphorylation of Fas-associated death domainGastric cancerDeath receptor-mediated apoptosisNormal gastric mucosal cellsNuclear expressionReceptor-mediated apoptosisCell cycle regulationNormal gastric cellsTissue microarray approachGlandular epithelial cellsDeath domainGastric mucosal cellsMicroarray approachClinocopathological characteristicsGastric adenocarcinomaGastric carcinomaEpithelial cellsCancer cellsMucosal cellsGastric cellsNormal cells
2006
Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas
Lee J, Jeong E, Soung Y, Nam S, Lee J, Yoo N, Lee S. Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas. Pathology 2006, 38: 312-315. PMID: 16916719, DOI: 10.1080/00313020600820880.Peer-Reviewed Original ResearchConceptsBif-1 expressionBax-interacting factor-1Bif-1Epithelial cellsIntrinsic pathwayIntrinsic pathway of apoptosisGastric carcinomaMalignant gastric epithelial cellsExpression of Bif-1Normal mucosal epithelial cellsNormal gastric mucosal cellsPathway of apoptosisMucosal cellsEvasion of apoptosisTissue microarray approachFactor 1Glandular epithelial cellsNormal mucosal cellsIntensity of immunostainingMucosal epithelial cellsGastric mucosal cellsHallmarks of cancerBax activationGastric epithelial cellsMicroarray approach
2004
Loss of caspase‐2, ‐6 and ‐7 expression in gastric cancers
YOO N, LEE J, KIM Y, SOUNG Y, KIM S, NAM S, PARK W, LEE J, LEE S. Loss of caspase‐2, ‐6 and ‐7 expression in gastric cancers. Apmis 2004, 112: 330-335. PMID: 15511269, DOI: 10.1111/j.1600-0463.2004.t01-1-apm1120602.x.Peer-Reviewed Original ResearchConceptsLoss of caspase-2Caspase-2Expression of caspase-2Normal gastric mucosal cellsMechanism of gastric cancer developmentApoptotic cell deathGastric cancer cellsCancer developmentHuman cancer developmentMicroarray approachCell deathGastric cancerGastric cancer developmentCancer cellsTissue microarray approachCaspaseSurface mucous cellsNormal gastric mucosaGastric mucosal cellsMucous cellsExpressionCellsGastric carcinomaMucosal cellsGastric mucosa
2003
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer
LEE S, LEE J, KIM H, KIM S, PARK W, KIM S, LEE J, YOO N. Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer. Apmis 2003, 111: 586-590. PMID: 12887511, DOI: 10.1034/j.1600-0463.2003.1110508.x.Peer-Reviewed Original ResearchConceptsInhibition of inhibitor of apoptosis proteinsOmi/HtrA2 expressionExpression of Omi/HtrA2Inhibitor of apoptosis proteinCaspase-independent mannerSerine protease Omi/HtrA2Caspase-dependent mannerRegulation of apoptosisCancer developmentAlteration of apoptosisCancer cell deathCancer cells in vivoApoptosis stimuliOmi/HtrA2Apoptosis proteinsImmunohistochemical analysisMicroarray approachExpression statusCell deathWeak expressionProtease activityAdvanced gastric adenocarcinomaMucous neck cellsApoptosisTissue microarray approach
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