2007
Immunohistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas
Yoo N, Lee J, Jeong E, Lee S. Immunohistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas. Digestive And Liver Disease 2007, 39: 222-227. PMID: 17267315, DOI: 10.1016/j.dld.2006.11.006.Peer-Reviewed Original ResearchConceptsPro-apoptotic membersPUMA protein expressionMutation analysisPUMA proteinPro-apoptotic member of Bcl-2 familyMembers of Bcl-2 familyGastric tumourigenesisMalignant gastric epithelial cellsSingle-strand conformation polymorphismBcl-2 familyGastric carcinomaMucosal epithelial cellsExpression of PUMAAlteration of apoptosisEpithelial cellsTarget of inactivationNormal mucosal epithelial cellsMechanisms of cancer developmentImmunohistochemical analysisGastric epithelial cellsP53-dependentProtein expressionPUMA expressionPUMA geneConformation polymorphism
2006
Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas
Lee J, Jeong E, Soung Y, Nam S, Lee J, Yoo N, Lee S. Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas. Pathology 2006, 38: 312-315. PMID: 16916719, DOI: 10.1080/00313020600820880.Peer-Reviewed Original ResearchConceptsBif-1 expressionBax-interacting factor-1Bif-1Epithelial cellsIntrinsic pathwayIntrinsic pathway of apoptosisGastric carcinomaMalignant gastric epithelial cellsExpression of Bif-1Normal mucosal epithelial cellsNormal gastric mucosal cellsPathway of apoptosisMucosal cellsEvasion of apoptosisTissue microarray approachFactor 1Glandular epithelial cellsNormal mucosal cellsIntensity of immunostainingMucosal epithelial cellsGastric mucosal cellsHallmarks of cancerBax activationGastric epithelial cellsMicroarray approachImmunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas
Lee J, Jeong E, Soung Y, Kim S, Nam S, Kim S, Lee J, Yoo N, Lee S. Immunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas. Pathology - Research And Practice 2006, 202: 497-501. PMID: 16723191, DOI: 10.1016/j.prp.2006.03.004.Peer-Reviewed Original ResearchConceptsApoptosis-inducing factor expressionApoptosis-inducing factorExpression of apoptosis-inducing factorMalignant gastric epithelial cellsExpression patternsGastric tumorigenesisNormal gastric mucosal cellsCaspase-independent apoptosisAdvanced gastric carcinomaDeath of cellsGastric epithelial cellsMitochondrial proteinsOxidoreductase functionGastric carcinomaMucosal cellsImmunohistochemical analysisNormal mucosal cellsParietal cellsGastric parietal cellsTumorigenesisDiffuse-type cancerDepth of invasionEpithelial cellsIntestinal-type cancerGastric mucosal cells
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