2019
Mitochondrial DNA stress signalling protects the nuclear genome
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Mitochondrial DNA stress signalling protects the nuclear genome. Nature Metabolism 2019, 1: 1209-1218. PMID: 32395698, PMCID: PMC7213273, DOI: 10.1038/s42255-019-0150-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell NucleusCytosolDNA DamageDNA-Binding ProteinsDNA, MitochondrialGenomeHigh Mobility Group ProteinsInterferon-Stimulated Gene Factor 3InterferonsMembrane ProteinsMiceMice, KnockoutMice, NudeNF-kappa BNucleotidyltransferasesProtein Serine-Threonine KinasesSignal TransductionConceptsMtDNA stressNuclear DNAGene expressionThousands of copiesMost cell typesRepair responseAcute antiviral responseNuclear genomeCircular mtDNAHigher-order structureInterferon gene expressionEssential proteinsMitochondrial DNACultured primary fibroblastsDNA stressUnphosphorylated formInterferon-stimulated gene expressionMouse melanoma cellsNDNA repairSignaling responseOxidative phosphorylationNDNA damageMtDNA damageMtDNAPrimary fibroblasts
2017
Histone demethylase KDM5B is critical for PI3K‐AKT‐mTOR signaling and stemness of melanoma
Yan Q, Zhang S, Meeth K, Micevic G, Bosenberg M. Histone demethylase KDM5B is critical for PI3K‐AKT‐mTOR signaling and stemness of melanoma. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.468.1.Peer-Reviewed Original ResearchKnockdown of KDM5BHistone demethylase KDM5BMTOR signalingPI3K-AktImmune checkpoint blockadeEpigenetic stateMouse melanoma cellsCancer stem cellsMouse melanoma modelMPC populationKDM5BMelanoma formationCheckpoint blockadeTumor initiationStem cellsMelanoma modelMelanoma cellsCareer Development AwardKnockdownSignalingPilot grantsMelanoma
1998
Melanoma × macrophage hybrids with enhanced metastatic potential
Rachkovsky M, Sodi S, Chakraborty A, Avissar Y, Bolognia J, Madison McNiff J, Platt J, Bermudes D, Pawelek J. Melanoma × macrophage hybrids with enhanced metastatic potential. Clinical & Experimental Metastasis 1998, 16: 299-312. PMID: 9626809, DOI: 10.1023/a:1006557228604.Peer-Reviewed Original ResearchConceptsHigh metastatic potentialMetastatic potentialMelanoma cellsTumor-infiltrating leukocytesParental melanoma cellsLow metastatic potentialB16F10 melanoma cellsFibroblast-conditioned mediumCloudman S91 mouse melanoma cellsMetastatic melanoma cellsS91 mouse melanoma cellsVascular invasionMetastatic melanomaPrimary tumorNormal miceMelanoma metastasesEnhanced metastasisMetastasisDistant organsUseful new modelMouse melanoma cellsHigher chemotaxisMetastatic linesHuman macrophagesTumor cells
1989
UVB-Induced melanogenesis may be mediated through the MSH-receptor system
Bolognia J, Murray M, Pawelek J. UVB-Induced melanogenesis may be mediated through the MSH-receptor system. Journal Of Investigative Dermatology 1989, 92: 651-656. DOI: 10.1016/0022-202x(89)90177-2.Peer-Reviewed Original ResearchMSH receptor activityUltraviolet B radiationReceptor activityMSH binding capacityMSH receptor systemMelanin-producing melanocytesUVB-induced melanogenesisHigh-affinity receptorGuinea pig skinEffects of UVBCloudman S91 mouse melanoma cellsS91 mouse melanoma cellsFamily of peptidesCutaneous melanocytesGuinea pigsMouse melanoma cellsAffinity receptorMelanoma cellsCellular responsivenessB radiationPig skinUVB lightCutaneous melanogenesisMelanocytesMSHUVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System
Bolognia J, Murray M, Pawelek J. UVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System. Journal Of Investigative Dermatology 1989, 92: 651-656. PMID: 2497190, DOI: 10.1111/1523-1747.ep12696836.Peer-Reviewed Original ResearchConceptsMSH receptor activityUltraviolet B radiationReceptor activityMSH binding capacityMSH receptor systemMelanin-producing melanocytesUVB-induced melanogenesisHigh-affinity receptorGuinea pig skinEffects of UVBCloudman S91 mouse melanoma cellsS91 mouse melanoma cellsFamily of peptidesCutaneous melanocytesGuinea pigsMouse melanoma cellsAffinity receptorMelanoma cellsCellular responsivenessB radiationPig skinUVB lightCutaneous melanogenesisMelanocytesMSH
1977
The dual effect of melanocyte-stimulating hormone (MSH) on the growth of cultured mouse melanoma cells
Halaban R, Lerner A. The dual effect of melanocyte-stimulating hormone (MSH) on the growth of cultured mouse melanoma cells. Experimental Cell Research 1977, 108: 111-117. PMID: 196867, DOI: 10.1016/s0014-4827(77)80016-5.Peer-Reviewed Original ResearchConceptsMelanocyte stimulating hormoneMouse melanoma cellsMelanoma cellsInhibition of growthTyrosinase activityIntracellular levelsRate of proliferationExogenous adenosineLow tyrosinase activityCyclic monophosphateHormoneDual effectHigh tyrosinase activityStimulationCellsActivation of tyrosinaseInhibitionStimulation of growthCulture mediumToxic substances
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