2009
Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia
Klein AM, Brash DE, Jones PH, Simons BD. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 107: 270-275. PMID: 20018764, PMCID: PMC2806764, DOI: 10.1073/pnas.0909738107.Peer-Reviewed Original ResearchConceptsP53 mutationsNonmelanoma skin cancer incidenceSame cumulative doseSkin cancer incidenceUVB radiationUV-irradiated epidermisP53 tumor suppressor geneP53-mutant clonesCumulative doseCancer incidenceP53 mutant cellsHigh-intensity exposureMurine epidermisPreneoplastic clonesTumor suppressor geneProgenitor cellsExposure resultsPrecancerous cellsPreneoplastic cellsHuman epidermisB radiationClones of cells
1999
UV Light and MSH Receptors
CHAKRABORTY A, FUNASAKA Y, SLOMINSKI A, BOLOGNIA J, SODI S, ICHIHASHI M, PAWELEK J. UV Light and MSH Receptors. Annals Of The New York Academy Of Sciences 1999, 885: 100-116. PMID: 10816644, DOI: 10.1111/j.1749-6632.1999.tb08668.x.Peer-Reviewed Original ResearchConceptsMSH receptorsSun-exposed areasAlpha-MSH receptorsSkin of miceMSH receptor activityPOMC-derived peptidesAction of UVBEffects of UVBGuinea pigsReceptor activityUVB irradiationUltraviolet B radiationReceptor productionCellular responsivenessReceptorsUVB damageB radiationSkin pigmentationUVBHuman melanocytesCutaneous melanogenesisMSHMelanin contentResultant increaseSkin
1989
UVB-Induced melanogenesis may be mediated through the MSH-receptor system
Bolognia J, Murray M, Pawelek J. UVB-Induced melanogenesis may be mediated through the MSH-receptor system. Journal Of Investigative Dermatology 1989, 92: 651-656. DOI: 10.1016/0022-202x(89)90177-2.Peer-Reviewed Original ResearchMSH receptor activityUltraviolet B radiationReceptor activityMSH binding capacityMSH receptor systemMelanin-producing melanocytesUVB-induced melanogenesisHigh-affinity receptorGuinea pig skinEffects of UVBCloudman S91 mouse melanoma cellsS91 mouse melanoma cellsFamily of peptidesCutaneous melanocytesGuinea pigsMouse melanoma cellsAffinity receptorMelanoma cellsCellular responsivenessB radiationPig skinUVB lightCutaneous melanogenesisMelanocytesMSHUVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System
Bolognia J, Murray M, Pawelek J. UVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System. Journal Of Investigative Dermatology 1989, 92: 651-656. PMID: 2497190, DOI: 10.1111/1523-1747.ep12696836.Peer-Reviewed Original ResearchConceptsMSH receptor activityUltraviolet B radiationReceptor activityMSH binding capacityMSH receptor systemMelanin-producing melanocytesUVB-induced melanogenesisHigh-affinity receptorGuinea pig skinEffects of UVBCloudman S91 mouse melanoma cellsS91 mouse melanoma cellsFamily of peptidesCutaneous melanocytesGuinea pigsMouse melanoma cellsAffinity receptorMelanoma cellsCellular responsivenessB radiationPig skinUVB lightCutaneous melanogenesisMelanocytesMSH
1983
Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.
Elmets C, Bergstresser P, Tigelaar R, Wood P, Streilein J. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. Journal Of Experimental Medicine 1983, 158: 781-794. PMID: 6193234, PMCID: PMC2187099, DOI: 10.1084/jem.158.3.781.Peer-Reviewed Original ResearchConceptsTolerogenic signalsLow-dose ultraviolet B (UVB) radiationLow-dose ultraviolet radiationAntigen-presenting potentialAntigen-specific unresponsivenessResident Langerhans cellsMechanism of unresponsivenessSuppressor cellsContact hypersensitivityLyt-1Effector stageLangerhans cellsSystemic administrationT cellsLocal applicationUltraviolet B radiationInduction phaseB radiationUnresponsivenessSkinUltraviolet radiationCellsTolerogenDNFBHypersensitivity
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