2017
Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters
Matos-Cruz V, Schneider ER, Mastrotto M, Merriman DK, Bagriantsev SN, Gracheva EO. Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters. Cell Reports 2017, 21: 3329-3337. PMID: 29262313, PMCID: PMC5741102, DOI: 10.1016/j.celrep.2017.11.083.Peer-Reviewed Original ResearchConceptsTransmembrane domainCold toleranceCold sensitivityGround squirrelsRat orthologMolecular adaptationsMammalian hibernatorsReciprocal mutationsAmino acidsFunctional significanceOrthologsSquirrelsMolecular prerequisitesActive stateHibernatorsTRPM8Somatosensory neuronsTolerancePoor activationSpeciesDomainMutationsResiduesHibernationCells
2009
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors*
Drag M, Bogyo M, Ellman JA, Salvesen GS. Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors*. Journal Of Biological Chemistry 2009, 285: 3310-3318. PMID: 19948737, PMCID: PMC2823418, DOI: 10.1074/jbc.m109.060418.Peer-Reviewed Original ResearchConceptsSubstrate specificityAminopeptidase NS1 pocketN-terminal amino acidsAmino acid substratesCell surface proteaseTypes of proteasesProteolytic eventsCell survivalRat orthologAcid substratesSurface proteaseSpecific inhibitorAmino acidsSubstrate hydrolysisCell compartmentTarget substrateAminopeptidasesGood substrateOptimal inhibitorSequential cleavageProteaseBioactive peptidesEukaryotesOrthologs
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