2006
Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4
Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4. Molecular And Cellular Biology 2006, 26: 831-842. PMID: 16428439, PMCID: PMC1347034, DOI: 10.1128/mcb.26.3.831-842.2006.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BlockingBreast NeoplasmsCell MovementCell ProliferationEnzyme ActivationErbB ReceptorsFemaleHumansNeoplasm ProteinsNeuregulin-1Phosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktReceptor, ErbB-2Receptor, ErbB-3Receptor, ErbB-4RNA Interferencesrc-Family KinasesTumor Cells, CulturedConceptsExtracellular signal-regulated kinaseHeregulin beta1RNA interferenceBreast cancer cellsCancer cellsActin cytoskeleton reorganizationDepletion of Rac1Activation of RacInactivation of RacTransactivation of EGFRSignal-regulated kinaseErbB receptor inhibitorsEpidermal growth factor receptorRho GTPasesMitogenic signalingRac activationRac GTPaseEpidermal growth factorGrowth factor receptorCytoskeleton reorganizationDownstream effectorsMitogenic activityCancer cell proliferationERK activationBreast cancer cell proliferation
2004
GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*
Bryan B, Kumar V, Stafford L, Cai Y, Wu G, Liu M. GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*. Journal Of Biological Chemistry 2004, 279: 45824-45832. PMID: 15322108, DOI: 10.1074/jbc.m406216200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalscdc42 GTP-Binding ProteinCells, CulturedGuanine Nucleotide Exchange FactorsHumansNeuritesNF-kappa Bp21-Activated KinasesProtein Serine-Threonine Kinasesrac1 GTP-Binding ProteinRatsRats, Sprague-DawleyRho Guanine Nucleotide Exchange FactorsTranscription Factor AP-1Transcriptional ActivationConceptsGuanine nucleotide exchange factorsNucleotide exchange factorsExchange factorRho family guanine nucleotide-exchange factorNeurite outgrowthState of Rac1Dendritic spine formationCell fate determinationActin cytoskeletal organizationExchange of GDPActivation of RacNormal cell growthRac1/Cdc42Spine formationFate determinationEukaryotic cellsGene regulationNeuroblastoma cellsSmall GTPasesActive GTPDbl familyRho familyCellular processesRho GTPasesCytoskeletal organization
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