2024
The Evolution of Mouse Models of Cancer: Past, Present, and Future
Abate-Shen C, Politi K. The Evolution of Mouse Models of Cancer: Past, Present, and Future. Cold Spring Harbor Perspectives In Medicine 2024, 15: a041736. PMID: 38772706, PMCID: PMC12047742, DOI: 10.1101/cshperspect.a041736.Peer-Reviewed Original ResearchPatient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations
Habowski A, Budagavi D, Scherer S, Aurora A, Caligiuri G, Flynn W, Langer E, Brody J, Sears R, Foggetti G, Estape A, Nguyen D, Politi K, Shen X, Hsu D, Peehl D, Kurhanewicz J, Sriram R, Suarez M, Xiao S, Du Y, Li X, Navone N, Labanca E, Willey C. Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations. Cancers 2024, 16: 565. PMID: 38339316, PMCID: PMC10854945, DOI: 10.3390/cancers16030565.Peer-Reviewed Original ResearchPatient-derived models of cancerPatient-derived modelsModels of cancerThe National Institutes of HealthCancer modelsNational Cancer Institute of the National Institutes of HealthPrecision medicine programsNational Institutes of HealthNational Cancer InstituteInstitutes of HealthPreclinical cancer modelsMedicine programsDivision of Cancer BiologyIn vitroIn vivo model systemsPractice recommendationsDevelopment of novel model systemsClinical practiceStudies of human pathologyNovel model systemsSeries of vignettesModel systemCancer therapeuticsCancer biologyCancer
2021
Personalized models of heterogeneous 3D epithelial tumor microenvironments: Ovarian cancer as a model
Horst EN, Bregenzer ME, Mehta P, Snyder CS, Repetto T, Yang-Hartwich Y, Mehta G. Personalized models of heterogeneous 3D epithelial tumor microenvironments: Ovarian cancer as a model. Acta Biomaterialia 2021, 132: 401-420. PMID: 33940195, PMCID: PMC8969826, DOI: 10.1016/j.actbio.2021.04.041.Peer-Reviewed Original ResearchConceptsOptimal adjuvant treatmentTumor microenvironmentOvarian cancerCancer modelAdverse clinical outcomesHeterogeneous patient populationMinimal residual diseaseDifferent tumor locationsConventional cancer treatmentsEpithelial tumor microenvironmentModels of cancerAdjuvant treatmentDurable responsesTreatment failureClinical outcomesResidual diseasePatient populationTumor locationDisease progressionEffective therapyFundamental cancer biologyDiverse tumor microenvironmentsIndividual patientsSame patientPatient biopsies
2014
The role of vitamin D in reducing cancer risk and progression
Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B. The role of vitamin D in reducing cancer risk and progression. Nature Reviews Cancer 2014, 14: 342-357. PMID: 24705652, DOI: 10.1038/nrc3691.Peer-Reviewed Original ResearchMeSH Keywords25-Hydroxyvitamin D3 1-alpha-HydroxylaseBreast NeoplasmsCalcitriolCholecalciferolColonic NeoplasmsDisease ProgressionEndocrine SystemFemaleHumansMaleNeoplasmsNeoplastic Stem CellsPolymorphism, GeneticPrognosisProstatic NeoplasmsRandomized Controlled Trials as TopicRiskSignal TransductionSteroid HydroxylasesVitamin DVitamin D DeficiencyVitamin D3 24-HydroxylaseConceptsVitamin D receptorReduce cancer riskCancer riskRandomized Controlled TrialsCancer developmentVitamin D3Vitamin DLow levels of circulating 25(OH)DLevels of circulating 25(OH)DAssociated with increased incidence of cancerCancer stem cell biologySingle nucleotide polymorphismsRisk of cancer developmentAnimal models of cancerAssociated with increased incidenceVitamin D deficiencyVitamin D supplementationLevels of calcitriolSteroid hormone calcitriolHuman clinical trialsRetarding cancer developmentModels of cancerStem cell biologyIncidence of cancerDietary vitamin D3
2013
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors
Hunter K, Palermo C, Kester J, Simpson K, Li J, Tang L, Klimstra D, Vlodavsky I, Joyce J. Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors. Oncogene 2013, 33: 1799-1808. PMID: 23644656, DOI: 10.1038/onc.2013.142.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease ProgressionFemaleFlow CytometryGlucuronidaseGTPase-Activating ProteinsHeparan Sulfate ProteoglycansHumansImmunohistochemistryLymphangiogenesisMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicNeoplasm InvasivenessNeovascularization, PathologicNeuroendocrine TumorsPancreatic NeoplasmsConceptsPancreatic neuroendocrine tumorsRIP1-Tag2PanNET patientsNeuroendocrine tumorsTumor invasionPresence of distant metastasesHuman pancreatic neuroendocrine tumorsHeparanase levelsRIP1-Tag2 modelMouse models of cancerHigh tumor gradeAdvanced tumor stageLymphangiogenesis in vivoSpontaneous mouse modelModels of cancerPromote tumor invasionDistant metastasisTumor gradeTumor stageTumor microenvironmentPotential therapeutic targetPericyte coverageIncreased angiogenesisPanNETsMouse model
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