2020
Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world
Koelmel JP, Napolitano MP, Ulmer CZ, Vasiliou V, Garrett TJ, Yost RA, Prasad MNV, Godri Pollitt KJ, Bowden JA. Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world. Metabolomics 2020, 16: 56. PMID: 32307636, DOI: 10.1007/s11306-020-01665-3.Peer-Reviewed Original ResearchConceptsNutrient cyclesEnvironmental stressorsDiverse biological rolesEnvironmental changesResponse of organismsEssential biological functionsHistorical environmental changesAnthropogenic induced changesClass of moleculesMillions of yearsLipidomics applicationsClimate changeBiological functionsMechanisms of toxicityBiological roleEcosystem responsesChemical environmentDirect targetPersistent compoundsCertain lipidsMolecular levelOrganismsGlobal climate changeMembrane fluidityMost toxinsProtein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit
Britton C, Sorrells T, Johnson A. Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit. Science 2020, 367: 96-100. PMID: 31896718, PMCID: PMC8284397, DOI: 10.1126/science.aax5217.Peer-Reviewed Original Research
1997
The Genetic Basis of Microbial Resistance to Antimicrobial Peptides
Groisman E, Aspedon A. The Genetic Basis of Microbial Resistance to Antimicrobial Peptides. Methods In Molecular Biology 1997, 78: 205-215. PMID: 9276306, DOI: 10.1385/0-89603-408-9:205.Peer-Reviewed Original ResearchConceptsSmall cationic peptidesAntimicrobial peptidesPathogen Salmonella typhimuriumDivergent organismsMillions of yearsMammalian hostsCationic peptidesGenetic basisAnimal hostsHost defense peptidesDiverse arrayHost tissuesInnate immunityVirulence propertiesDefense peptidesHostChemical barrierSalmonella typhimuriumMicroorganismsMicrobial resistanceS. typhimuriumPeptidesEnteric pathogensAntibiotic propertiesOpportunistic microorganisms
1990
Regulation of the segmentation gene fushi tarazu has been functionally conserved in Drosophila.
Maier D, Preiss A, Powell J. Regulation of the segmentation gene fushi tarazu has been functionally conserved in Drosophila. The EMBO Journal 1990, 9: 3957-3966. PMID: 2174353, PMCID: PMC552166, DOI: 10.1002/j.1460-2075.1990.tb07616.x.Peer-Reviewed Original ResearchConceptsSegmentation gene fushi tarazuFtz geneFushi tarazuD. melanogasterUpstream elementEvolution of DrosophilaEntire regulatory networksSegmentation genesMillions of yearsRegulatory networksRegulatory elementsStrong homologySpecific enhancersGene productsUpstream regionUnrelated sequencesTransformation experimentsGenesDrosophilaMelanogasterOverall organizationRegulationFTZHomologuesHomology
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