2020
Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients
Wong S, Hui P, Buza N. Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients. Modern Pathology 2020, 33: 1172-1181. PMID: 31932681, DOI: 10.1038/s41379-020-0455-x.Peer-Reviewed Original ResearchConceptsLynch syndrome patientsLynch syndromeMMR protein expressionSporadic endometrial carcinomasSyndrome patientsEndometrial cancerEndometrial glandsEndometrial carcinomaProtein expressionLynch syndrome-associated endometrial cancerGermline mutationsMismatch repair protein expressionMMR protein immunohistochemistryEndometrial cancer patientsNonneoplastic endometriumBenign endometrial tissuesMicrosatellite instability testingMMR protein lossGermline mutation analysisDNA mismatch repair genesRepair protein expressionMismatch repair genesBackground endometriumMMR immunohistochemistryProphylactic hysterectomy
2016
Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition
Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition. Histopathology 2016, 70: 223-231. PMID: 27560620, PMCID: PMC5921077, DOI: 10.1111/his.13068.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionColorectal carcinomaDistant metastasisImmunohistochemical evidenceEvidence of EMTAdvanced T categoryConventional colorectal carcinomaCystic nodal metastasisStage IV diseaseAdvanced local diseaseLymph node metastasisMicrosatellite instability testingBRAF V600E mutationMedian survivalMucinous featuresOverall survivalNodal metastasisNode metastasisLocal diseaseMicropapillary featuresT categoryDirty necrosisCribriform patternKRAS mutationsProminent necrosis
2005
Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the Identification of Patients With Hereditary Nonpolyposis Colorectal Cancer
Piñol V, Castells A, Andreu M, Castellví-Bel S, Alenda C, Llor X, Xicola RM, Rodríguez-Moranta F, Payá A, Jover R, Bessa X, Association F. Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the Identification of Patients With Hereditary Nonpolyposis Colorectal Cancer. JAMA 2005, 293: 1986-1994. PMID: 15855432, DOI: 10.1001/jama.293.16.1986.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAgedCarrier ProteinsChromosomal InstabilityColorectal Neoplasms, Hereditary NonpolyposisCost-Benefit AnalysisDNA Mutational AnalysisDNA-Binding ProteinsFemaleGenetic Carrier ScreeningGenetic TestingGerm-Line MutationGuidelines as TopicHeterozygoteHumansImmunohistochemistryMaleMicrosatellite RepeatsMiddle AgedMutL Protein Homolog 1MutS Homolog 2 ProteinNeoplasm ProteinsNuclear ProteinsPredictive Value of TestsProspective StudiesProto-Oncogene ProteinsSensitivity and SpecificitySpainConceptsMicrosatellite instability testingBethesda guidelinesMLH1 germline mutationsInstability testingMicrosatellite instabilityGermline testingColorectal cancerGermline mutationsHereditary nonpolyposis colorectal cancerRevised Bethesda GuidelinesProtein expressionIdentification of patientsLogistic regression analysisNonpolyposis colorectal cancerMismatch repair deficiencyNational Cancer InstituteCancer genetic testingTumor characteristicsClinical parametersFamily historyNationwide studyIdentification of individualsCancer InstitutePatientsGenetic testingValue of Immunohistochemical Detection of DNA Mismatch Repair Proteins in Predicting Germline Mutation in Hereditary Colorectal Neoplasms
Shia J, Klimstra D, Nafa K, Offit K, Guillem J, Markowitz A, Gerald W, Ellis N. Value of Immunohistochemical Detection of DNA Mismatch Repair Proteins in Predicting Germline Mutation in Hereditary Colorectal Neoplasms. The American Journal Of Surgical Pathology 2005, 29: 96-104. PMID: 15613860, DOI: 10.1097/01.pas.0000146009.85309.3b.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdenomaAdultAgedBase Pair MismatchBiomarkers, TumorCarrier ProteinsColorectal NeoplasmsDNA Mutational AnalysisDNA-Binding ProteinsDNA, NeoplasmFemaleGerm-Line MutationHumansImmunoenzyme TechniquesMaleMicrosatellite RepeatsMiddle AgedMutL Protein Homolog 1MutS Homolog 2 ProteinNeoplasm ProteinsNuclear ProteinsProto-Oncogene ProteinsConceptsHereditary nonpolyposis colorectal cancerMicrosatellite instability testingFamily history of colorectal cancerIdentification of HNPCC familiesHistory of colorectal cancerGermline mutationsMismatch repair proteinsNonpolyposis colorectal cancerMLH1 germline mutationMSH2 germline mutationsMLH1 gene mutationColorectal cancerMicrosatellite instabilityMismatch repair mutationsMismatch repairHNPCC familiesMSH6 casesGermline mutation carriersPredicting mutation statusMSH6 geneColorectal neoplasmsIdentification of personsPredicting MSI statusFamily historyStudy sample
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