2005
Value of Immunohistochemical Detection of DNA Mismatch Repair Proteins in Predicting Germline Mutation in Hereditary Colorectal Neoplasms
Shia J, Klimstra D, Nafa K, Offit K, Guillem J, Markowitz A, Gerald W, Ellis N. Value of Immunohistochemical Detection of DNA Mismatch Repair Proteins in Predicting Germline Mutation in Hereditary Colorectal Neoplasms. The American Journal Of Surgical Pathology 2005, 29: 96-104. PMID: 15613860, DOI: 10.1097/01.pas.0000146009.85309.3b.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdenomaAdultAgedBase Pair MismatchBiomarkers, TumorCarrier ProteinsColorectal NeoplasmsDNA Mutational AnalysisDNA-Binding ProteinsDNA, NeoplasmFemaleGerm-Line MutationHumansImmunoenzyme TechniquesMaleMicrosatellite RepeatsMiddle AgedMutL Protein Homolog 1MutS Homolog 2 ProteinNeoplasm ProteinsNuclear ProteinsProto-Oncogene ProteinsConceptsHereditary nonpolyposis colorectal cancerMicrosatellite instability testingFamily history of colorectal cancerIdentification of HNPCC familiesHistory of colorectal cancerGermline mutationsMismatch repair proteinsNonpolyposis colorectal cancerMLH1 germline mutationMSH2 germline mutationsMLH1 gene mutationColorectal cancerMicrosatellite instabilityMismatch repair mutationsMismatch repairHNPCC familiesMSH6 casesGermline mutation carriersPredicting mutation statusMSH6 geneColorectal neoplasmsIdentification of personsPredicting MSI statusFamily historyStudy sample
2003
Value of Histopathology in Predicting Microsatellite Instability in Hereditary Nonpolyposis Colorectal Cancer and Sporadic Colorectal Cancer
Shia J, Ellis N, Paty P, Nash G, Qin J, Offit K, Zhang X, Markowitz A, Nafa K, Guillem J, Wong W, Gerald W, Klimstra D. Value of Histopathology in Predicting Microsatellite Instability in Hereditary Nonpolyposis Colorectal Cancer and Sporadic Colorectal Cancer. The American Journal Of Surgical Pathology 2003, 27: 1407-1417. PMID: 14576473, DOI: 10.1097/00000478-200311000-00002.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCarrier ProteinsColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisDNA Mutational AnalysisDNA-Binding ProteinsDNA, NeoplasmFemaleGerm-Line MutationHumansLymphocytes, Tumor-InfiltratingMaleMicrosatellite RepeatsMiddle AgedMutL Protein Homolog 1MutS Homolog 2 ProteinNeoplasm ProteinsNuclear ProteinsPredictive Value of TestsProto-Oncogene ProteinsROC CurveSensitivity and SpecificityConceptsSporadic MSI-H tumorsHereditary nonpolyposis colorectal cancerNonpolyposis colorectal cancerMSI-H tumorsColorectal cancerFamily history of colorectal cancerHistory of colorectal cancerFamily historyHNPCC-associated cancersLevels of DNA microsatellite instabilityMSI-HDNA microsatellite instabilitySporadic colorectal cancerLogistic regression modelsAmsterdam criteriaMicrosatellite instabilityNon-MSI-H tumorsHNPCCOdds ratioPredicting MSI statusColorectal carcinomaSporadic groupTumor-infiltrating lymphocytesMSI-H colorectal carcinomasSurgical clinic
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