2016
Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition
Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition. Histopathology 2016, 70: 223-231. PMID: 27560620, PMCID: PMC5921077, DOI: 10.1111/his.13068.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionColorectal carcinomaDistant metastasisImmunohistochemical evidenceEvidence of EMTAdvanced T categoryConventional colorectal carcinomaCystic nodal metastasisStage IV diseaseAdvanced local diseaseLymph node metastasisMicrosatellite instability testingBRAF V600E mutationMedian survivalMucinous featuresOverall survivalNodal metastasisNode metastasisLocal diseaseMicropapillary featuresT categoryDirty necrosisCribriform patternKRAS mutationsProminent necrosis
2008
Adenoma-infiltrating Lymphocytes (AILs) are a Potential Marker of Hereditary Nonpolyposis Colorectal Cancer
Polydorides A, Mukherjee B, Gruber S, McKenna B, Appelman H, Greenson J. Adenoma-infiltrating Lymphocytes (AILs) are a Potential Marker of Hereditary Nonpolyposis Colorectal Cancer. The American Journal Of Surgical Pathology 2008, 32: 1661-1666. PMID: 18753941, PMCID: PMC3500084, DOI: 10.1097/pas.0b013e31816ffa80.Peer-Reviewed Original ResearchConceptsHereditary nonpolyposis colorectal cancer syndromeColorectal adenomasControl adenomasHereditary nonpolyposis colorectal cancer patientsColorectal cancer syndromePresence of high-grade dysplasiaTumor-infiltrating lymphocytesHigh-grade dysplasiaPresence of necrosisNumbers of mitotic figuresColorectal cancer patientsHost immune responseVillous componentCancer syndromesLack of dirty necrosisSerrated architectureMicrosatellite-unstable colorectal cancersPatient ageGeneral populationPoor differentiationDirty necrosisInexpensive markerHistological featuresColorectal cancerAdenomas
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