2024
Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice
Yang X, Xu Y, Li J, Ran X, Gu Z, Song L, Zhang L, Wen L, Ji G, Wang R. Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice. MSystems 2024, 9: e00127-24. PMID: 38934542, PMCID: PMC11265269, DOI: 10.1128/msystems.00127-24.Peer-Reviewed Original ResearchGut microbiotaGut microbiota dysbiosisDysregulated gut microbiotaGut microbiota transplantationGerm-free miceVirulence factorsSmall intestinal bacteriaBile acid homeostasisMicrobiota dysbiosisDecreased diversityMicrobiota imbalanceMicrobiotaMouse model of cholestasisBile acidsMouse modelIntestinal bacteriaAcid homeostasisMicrobiota transplantationClinical management of patientsGutHepatic bile acidsLong-term effectsPre-clinical findingsModel of cholestasisManagement of patients
2022
Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease
Liang T, Li D, Zunong J, Li M, Amaerjiang N, Xiao H, Khattab N, Vermund S, Hu Y. Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease. Nutrients 2022, 14: 4641. PMID: 36364902, PMCID: PMC9657134, DOI: 10.3390/nu14214641.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHigher lymphocyte countsLymphocyte countGut microbiotaLiver diseaseHealthy childrenGut microbiota dysbiosisEffect of lymphocytesProinflammatory bacteriaMicrobiota dysbiosisRisk factorsIntestinal microbiotaAbundance of BacteroidetesLymphocytesMicrobiotaChildrenOpportunistic pathogenDiseaseCountMetagenomic sequencingLow numberHigher numberDysbiosisGroupObesity aggravates contact hypersensitivity reaction in mice
Majewska‐Szczepanik M, Kowalczyk P, Marcińska K, Strzępa A, Lis GJ, Wong FS, Szczepanik M, Wen L. Obesity aggravates contact hypersensitivity reaction in mice. Contact Dermatitis 2022, 87: 28-39. PMID: 35234303, PMCID: PMC9949724, DOI: 10.1111/cod.14088.Peer-Reviewed Original ResearchConceptsContact hypersensitivityFecal microbiota transplantationQuantitative polymerase chain reactionIL-17AObese miceEnhanced contact hypersensitivityGut microbiota dysbiosisLow-grade inflammationContact hypersensitivity reactionInfluence of obesityInflammatory skin diseaseT helper 1Antigen-specific responsesHigh-fat dietSubcutaneous adipose tissueProinflammatory CD4Proinflammatory milieuCytokine profileMicrobiota dysbiosisDendritic cellsLymph nodesMicrobiota transplantationHelper 1Hypersensitivity reactionsImmune cells
2021
Lung microbiome alterations in NSCLC patients
Zheng L, Sun R, Zhu Y, Li Z, She X, Jian X, Yu F, Deng X, Sai B, Wang L, Zhou W, Wu M, Li G, Tang J, Jia W, Xiang J. Lung microbiome alterations in NSCLC patients. Scientific Reports 2021, 11: 11736. PMID: 34083661, PMCID: PMC8175694, DOI: 10.1038/s41598-021-91195-2.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNon-small cell lung cancer patientsRare speciesOral taxaLung microbiotaDiverse array of microbesNon-cancer controlsLobectomy samplesArray of microbesGlobal microbial compositionAssociated with lung cancer progressionLung cancerLung microbiome compositionBronchoscopy samplesPseudomonas entomophilaMetagenomic sequencingBronchoalveolar lavageLactobacillus rossiaeBacteroides pyogenesMicrobiota dysbiosisMicrobial communitiesMicrobiome compositionPaenibacillus odoriferMicrobial compositionLung microbiota dysbiosis
2019
IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM
Catanzaro JR, Strauss JD, Bielecka A, Porto AF, Lobo FM, Urban A, Schofield WB, Palm NW. IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. Scientific Reports 2019, 9: 13574. PMID: 31537840, PMCID: PMC6753154, DOI: 10.1038/s41598-019-49923-2.Peer-Reviewed Original ResearchConceptsGut microbiota compositionOverall microbial diversityHost-microbiota symbiosisSpecific microbial taxaGut microbial communityHuman gut microbiota compositionNon-redundant roleRRNA gene sequencingMicrobiota compositionMicrobial taxaMicrobial communitiesMicrobial diversityHealthy controlsSecretory IgAMucosal secretionsIgA-deficient humansBacterial cellsRelative abundanceAltered gut microbiota compositionGene sequencingDominant antibody isotypeDefined subsetsGut microbiota dysbiosisMicrobiotaMicrobiota dysbiosis
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