2024
1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice
SRODA N, VIJAYAKUMAR A, MURAKAMI E, WENG S, SHULMAN G, MYERS R, SUBRAMANIAN M. 1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice. Diabetes 2024, 73 DOI: 10.2337/db24-1637-p.Peer-Reviewed Original ResearchEnergy intakeWeight lossEnergy expenditureRespiratory exchange ratioMitochondrial protonophoreObese miceDose-dependent weight lossReduced oral intakeData support evaluationDays of dosingC57 BL/6 miceDiet-induced obese miceNegative energy balanceMale C57 BL/6 miceIncreased energy expenditureWhole-body lipid utilizationCompared to pre-treatmentHigh-fat dietOral intakePo bidBL/6 miceIndirect calorimetryMetabolic benefitsLipid utilizationVEH
2017
Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms
Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e9172-e9180. PMID: 29073114, PMCID: PMC5664516, DOI: 10.1073/pnas.1707797114.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseDe novo lipogenesisAdipose tissue lipolysisHepatic insulin resistanceThyroid hormonesHypothyroid miceImpaired suppressionInsulin resistanceTissue lipolysisInsulin secretionHigh thyroid-stimulating hormone levelsRegulation of THThyroid-stimulating hormone levelsLipid utilizationFatty liver diseaseSerum glucose levelsEndogenous glucose productionLow thyroid hormoneFatty acidsHepatic lipid utilizationLiver diseaseSevere hypothyroidismHormone levelsProfound suppressionGlucose levels
2015
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver
Martinez-Lopez N, Garcia-Macia M, Sahu S, Athonvarangkul D, Liebling E, Merlo P, Cecconi F, Schwartz GJ, Singh R. Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver. Cell Metabolism 2015, 23: 113-127. PMID: 26698918, PMCID: PMC4715637, DOI: 10.1016/j.cmet.2015.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytes, BrownAdipose Tissue, BrownAmino Acid SequenceAnimalsAutophagyCold TemperatureFemaleHypothalamusLipaseLipid DropletsLipolysisLiverLysosomesMaleMice, Inbred C57BLMice, TransgenicMicrotubule-Associated ProteinsMolecular Sequence DataNeuronsOxygen ConsumptionPro-OpiomelanocortinConceptsBrown adipose tissuePOMC neuronsLipid utilizationPeripheral tissuesAdipose tissueProopiomelanocortin neuronsInter-organ communicationCentral autophagyCold-induced activationATGLAutophagosome marker LC3LipolysisNeuronsTargeted activationLipase ATGLLipophagyIntegrative physiologyTissueMiceLiverAutophagyAutophagy proteinsCytosolic lipasesCold inducesActivation
2012
AgRP neurons: a switch between peripheral carbohydrate and lipid utilization
Varela L, Horvath TL. AgRP neurons: a switch between peripheral carbohydrate and lipid utilization. The EMBO Journal 2012, 31: 4252-4254. PMID: 23085989, PMCID: PMC3501218, DOI: 10.1038/emboj.2012.287.Peer-Reviewed Original Research
2000
Intramuscular Glycogen and Intramyocellular Lipid Utilization during Prolonged Exercise and Recovery in Man: A 13C and 1H Nuclear Magnetic Resonance Spectroscopy Study1
Krssak M, Petersen K, Bergeron R, Price T, Laurent D, Rothman D, Roden M, Shulman G. Intramuscular Glycogen and Intramyocellular Lipid Utilization during Prolonged Exercise and Recovery in Man: A 13C and 1H Nuclear Magnetic Resonance Spectroscopy Study1. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 748-754. PMID: 10690886, DOI: 10.1210/jcem.85.2.6354.Peer-Reviewed Original ResearchProlonged exerciseIMCL contentGlycogen contentBaseline valuesSoleus muscleMuscle glycogenMuscle groupsGreater muscle glycogen utilizationForearm musclesGlycogen concentrationLipid utilizationIntramyocellular lipid poolMuscle glycogen utilizationCalf muscle groupThigh muscle groupsIntramyocellular glycogenNonexercising muscleIntramuscular glycogenGlycogen depletionGlycogen utilizationTime of exhaustionLeg musclesThigh musclesSubmaximal intensitiesMuscle
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