2023
Improved benefit of continuing luspatercept therapy: sub-analysis of patients with lower-risk MDS in the MEDALIST study
Germing U, Fenaux P, Platzbecker U, Buckstein R, Santini V, Díez-Campelo M, Yucel A, Tang D, Fabre S, Zhang G, Zoffoli R, Ha X, Miteva D, Hughes C, Komrokji R, Zeidan A, Garcia-Manero G. Improved benefit of continuing luspatercept therapy: sub-analysis of patients with lower-risk MDS in the MEDALIST study. Annals Of Hematology 2023, 102: 311-321. PMID: 36635381, PMCID: PMC9889415, DOI: 10.1007/s00277-022-05071-8.Peer-Reviewed Original ResearchConceptsRBC transfusion burdenTransfusion burdenWeek 25Transfusion unitsRBC-TIInitial nonrespondersHemoglobin levelsErythroid responseClinical benefitRed blood cell transfusion independenceLower-risk myelodysplastic syndromesPlacebo-treated patientsSerum ferritin levelsAdditional clinical benefitWeeks of treatmentLower-risk MDSTransfusion independenceFerritin levelsSerum ferritinMyelodysplastic syndromeRing sideroblastsPatientsClinical practiceLuspaterceptMaximum dose
2021
Reirradiation With Stereotactic Radiosurgery After Local or Marginal Recurrence of Brain Metastases From Previous Radiosurgery
Kowalchuk RO, Niranjan A, Lee CC, Yang HC, Liscak R, Guseynova K, Tripathi M, Kumar N, Peker S, Samanci Y, Hess J, Chiang V, Iorio-Morin C, Mathieu D, Pikis S, Wei Z, Lunsford LD, Trifiletti DM, Sheehan JP. Reirradiation With Stereotactic Radiosurgery After Local or Marginal Recurrence of Brain Metastases From Previous Radiosurgery. International Journal Of Radiation Oncology • Biology • Physics 2021, 112: 726-734. PMID: 34644606, DOI: 10.1016/j.ijrobp.2021.10.008.Peer-Reviewed Original ResearchConceptsLocal tumor controlRepeat stereotactic radiosurgeryRadiation necrosisStereotactic radiosurgeryBrain metastasesTumor controlMaximum doseMarginal recurrenceBiopsy-proven non-small cell lung cancerIsodose lineNon-small cell lung cancerRisk of RNPreoperative stereotactic radiosurgeryPrior stereotactic radiosurgerySymptomatic radiation necrosisNeuro-Oncology criteriaCell lung cancerPrescription isodose linePrevious radiosurgeryMargin dosePrimary endpointPrior immunotherapyLung cancerMajor indicationTumor volume
2020
MDS-175: Assessment of Dose-Dependent Response to Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes (LR-MDS) with Ring Sideroblasts (RS) in the Phase 3 MEDALIST Trial
Platzbecker U, Fenaux P, Mufti G, Garcia-Manero G, Komrokji R, Buckstein R, Diez-Campelo M, Finelli C, Sekeres M, Selleslag D, DeZern A, Quesnel B, Beyne-Rauzy O, Voso M, Greenberg P, Zeidan A, Adès L, Verma A, Savona M, Laadem A, Ito R, Zhang J, Rampersad A, Morison J, Louis C, Linde P, Santini V. MDS-175: Assessment of Dose-Dependent Response to Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes (LR-MDS) with Ring Sideroblasts (RS) in the Phase 3 MEDALIST Trial. Clinical Lymphoma Myeloma & Leukemia 2020, 20: s318. DOI: 10.1016/s2152-2650(20)30972-1.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsLower-risk myelodysplastic syndromesRBC-TIRing sideroblastsDose levelsDose reductions/delaysMaximum doseLR-MDS patientsRBC transfusion independenceMajority of patientsMaintenance of responseSame dose levelFirst responseDose delaysDose-dependent responseEligible patientsDose titrationNew onsetTransfusion burdenTransfusion independenceAdverse eventsDose escalationMedian timeMyelodysplastic syndromeHemoglobin increaseTemporal Lobe Necrosis in Head and Neck Cancer Patients after Proton Therapy to the Skull Base
Kitpanit S, Lee A, Pitter KL, Fan D, Chow JCH, Neal B, Han Z, Fox P, Sine K, Mah D, Dunn LA, Sherman EJ, Michel L, Ganly I, Wong RJ, Boyle JO, Cohen MA, Singh B, Brennan CW, Gavrilovic IT, Hatzoglou V, O'Malley B, Zakeri K, Yu Y, Chen L, Gelblum DY, Kang JJ, McBride SM, Tsai CJ, Riaz N, Lee NY. Temporal Lobe Necrosis in Head and Neck Cancer Patients after Proton Therapy to the Skull Base. International Journal Of Particle Therapy 2020, 6: 17-28. PMID: 32582816, PMCID: PMC7302730, DOI: 10.14338/ijpt-20-00014.1.Peer-Reviewed Original ResearchMagnetic resonance imagingRadiation-naïve patientsDose-volume parametersSkull baseNeck cancerTemporal lobeCutoff valueMaximum doseProton therapyAdverse Events v5.0Common Terminology CriteriaTemporal lobe necrosisNeck cancer patientsDose-volume factorsTerminology CriteriaMedian followBrain necrosisMedian timeClinical parametersCancer patientsMedical recordsGrade 3Necrosis rateField of radiationPatients
2016
Pulmonary dose-volume predictors of radiation pneumonitis following stereotactic body radiation therapy
Harder EM, Park HS, Chen Z, Decker RH. Pulmonary dose-volume predictors of radiation pneumonitis following stereotactic body radiation therapy. Practical Radiation Oncology 2016, 6: e353-e359. PMID: 27156424, DOI: 10.1016/j.prro.2016.01.015.Peer-Reviewed Original ResearchConceptsMean lung doseStereotactic body radiation therapyRisk of gradeRadiation pneumonitisMultivariable logistic regressionBody radiation therapyDosimetric predictorsRadiation therapyMaximum doseLogistic regressionRP rateBest dosimetric predictorCardiac dosimetric parametersDose-volume predictorsPercent of lungVolume of lungGross tumor volumeBackward stepwise eliminationLung V10Lung doseMean doseTotal lungUnivariate analysisPulmonary volumesTumor volume
2014
SU‐E‐T‐518: Dosiemtric Impact of Patient Positioning Uncertainty in SBRT Treatments
Abbas H, Abolfath R, Nath R, Chen Z. SU‐E‐T‐518: Dosiemtric Impact of Patient Positioning Uncertainty in SBRT Treatments. Medical Physics 2014, 41: 346-346. DOI: 10.1118/1.4888851.Peer-Reviewed Original ResearchPatient positioning uncertaintiesDosimetric impactSuperior-inferior directionTreatment planLung SBRTCourse of treatmentSpine SBRT patientsOriginal treatment planLung doseCertain patientsAnterior-posterior positionPractice guidelinesIsocenter positioningSBRT treatmentSBRT patientsMinimum doseMaximum doseSBRTPatientsDoseMinimal dosimetric impactSpine SBRTProstateMonitor unitsTreatment planning systemEfficiency gains for spinal radiosurgery using multicriteria optimization intensity modulated radiation therapy guided volumetric modulated arc therapy planning
Chen H, Winey BA, Daartz J, Oh KS, Shin JH, Gierga DP. Efficiency gains for spinal radiosurgery using multicriteria optimization intensity modulated radiation therapy guided volumetric modulated arc therapy planning. Practical Radiation Oncology 2014, 5: 49-55. PMID: 25413420, PMCID: PMC4289020, DOI: 10.1016/j.prro.2014.04.003.Peer-Reviewed Original ResearchConceptsMCO-IMRTSpinal cordVMAT plansSpinal radiosurgeryRadiation therapyPlan qualityMonitor unitsTarget volume coverageArc therapy (VMAT) planningTotal monitor unitsDose-volume histogram constraintsSpinal metastasesStereotactic radiosurgeryPrescribed doseRisk volumeArc therapyMaximum doseConformity numberHomogeneity indexDVH constraintsVMATTherapyVolume coverageRadiosurgeryTarget coverage
2013
SU‐E‐T‐438: Dosimetric Effect of Patient Arm Position in Spinal CyberKnife Robotic Radiosurgery
Mihaylov I, Tien C, Hepel J. SU‐E‐T‐438: Dosimetric Effect of Patient Arm Position in Spinal CyberKnife Robotic Radiosurgery. Medical Physics 2013, 40: 306-306. DOI: 10.1118/1.4814872.Peer-Reviewed Original ResearchPTV coverageSpinal cordMinimum doseExtremity motionDosimetric effectsPatient's arm positionArm positionCyberKnife robotic radiosurgeryPotential dosimetric effectsPrescription dosesSpinal lesionsCyberKnife radiosurgerySpine lesionsCyberKnife treatmentSupine positionTreatment planPatientsMaximum dosePatient's armComparison plansCritical organsMean differenceRobotic radiosurgeryDoseDosimetric impact
2007
Aripiprazole as an adjunctive treatment for refractory unipolar depression
Hellerstein DJ, Batchelder S, Hyler S, Arnaout B, Corpuz V, Coram L, Weiss G. Aripiprazole as an adjunctive treatment for refractory unipolar depression. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2007, 32: 744-750. PMID: 18164528, DOI: 10.1016/j.pnpbp.2007.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntipsychotic AgentsAripiprazoleBrief Psychiatric Rating ScaleDepressive DisorderDiagnostic and Statistical Manual of Mental DisordersDrug Administration ScheduleDrug EvaluationFemaleHumansMaleMiddle AgedPiperazinesProspective StudiesQuinolonesSocial BehaviorTime FactorsTreatment OutcomeConceptsHDRS-24Adjunctive treatmentSNRI medicationsUnipolar depressionCurrent episodeWeek open label studyTreatment-resistant major depressionCurrent DSM-IV diagnosisEffectiveness of aripiprazoleRefractory unipolar depressionOpen-label studyEffective adjunctive treatmentDSM-IV diagnosisFluoxetine equivalentsSNRI treatmentWeek 12Baseline severityMean doseMajor depressionTreatment respondersSide effectsSSRIsMaximum doseAripiprazoleMedications
2003
A comparative dosimetric study on tangential photon beams, intensity-modulated radiation therapy (IMRT) and modulated electron radiotherapy (MERT) for breast cancer treatment
Ma C, Ding M, Li JS, Lee MC, Pawlicki T, Deng J. A comparative dosimetric study on tangential photon beams, intensity-modulated radiation therapy (IMRT) and modulated electron radiotherapy (MERT) for breast cancer treatment. Physics In Medicine And Biology 2003, 48: 909-924. PMID: 12701895, DOI: 10.1088/0031-9155/48/7/308.Peer-Reviewed Original ResearchConceptsIntensity-modulated radiation therapyTangential photon beamsContralateral breastBreast cancerRadiation therapyTreatment planMaximum doseBreast cancer treatmentTreatment optimizationComparative dosimetric studyBreast treatment plansPhoton treatment plansPhoton beamsElectron radiotherapySuperficial targetsMultiple beam anglesLungMedium dosesDose conformityTangential beamsNormal tissuesCancer treatmentMERT plansIMRT plansMV photon beam
2001
The MLC tongue-and-groove effect on IMRT dose distributions
Deng J, Pawlicki T, Chen Y, Li J, Jiang S, Ma C. The MLC tongue-and-groove effect on IMRT dose distributions. Physics In Medicine And Biology 2001, 46: 1039-1060. PMID: 11324950, DOI: 10.1088/0031-9155/46/4/310.Peer-Reviewed Original Research
2000
Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis
Waksman R, Bhargava B, Mintz G, Mehran R, Lansky A, Satler L, Pichard A, Kent K, Leon M. Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis. Journal Of The American College Of Cardiology 2000, 36: 65-68. PMID: 10898414, DOI: 10.1016/s0735-1097(00)00681-1.Peer-Reviewed Original ResearchConceptsLate total occlusionPlacebo patientsStent restenosisIntracoronary radiationIrradiated groupAntiplatelet therapyTotal occlusionAcute myocardial infarctionEntire study groupUnstable anginaIntracoronary brachytherapyMyocardial infarctionRadiation protocolStudy groupLate thrombosisPatientsRestenosisMultivariate analysisMaximum doseMean timeNew stentTime of radiationVessel wallMonthsOverall rate
1999
Differential bronchodilatory effects of terbutaline, diltiazem, and aminophylline in canine intraparenchymal airways
Akhtar S, Mazzeo A, Cheng E, Bosnjak Z, Kampine J. Differential bronchodilatory effects of terbutaline, diltiazem, and aminophylline in canine intraparenchymal airways. Critical Care Medicine 1999, 27: 1551-1556.. PMID: 10470763, DOI: 10.1097/00003246-199908000-00024.Peer-Reviewed Original ResearchConceptsIntraparenchymal airwaysVolatile anestheticsAdministration of terbutalineAnimal research laboratoryDose-response curveAirway ringsDistal airwaysTissue bathAdult dogsIsometric tensionMaximum doseAirwayBronchodilatorsAminophyllineTerbutalineAnestheticsEffective concentrationMaximum responseDogsTopographic locationFlow regulationBronchiolusBronchusAcetylcholineGreater degree
1998
Management of the Adverse Effects of Clozapine
Young CR, Bowers MB, Mazure CM. Management of the Adverse Effects of Clozapine. Schizophrenia Bulletin 1998, 24: 381-390. PMID: 9718630, DOI: 10.1093/oxfordjournals.schbul.a033333.Peer-Reviewed Original ResearchConceptsAdverse effectsElevated liver enzymesPercent of patientsSuccessful pharmacological managementPositive therapeutic outcomesHypothesized pathophysiologyPharmacological managementRefractory schizophreniaNeuromuscular effectsTraditional neurolepticsLiver enzymesPharmacological interventionsClozapineAffective disordersTherapeutic outcomesNeurological disordersMental disordersMaximum doseObsessive-compulsive symptomsWeight gainDisordersPatientsPathophysiologyNew hopeTreatment
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