2006
Osteogenic Protein-1 Induced Gene Expression: Evaluation in a Posterolateral Spinal Pseudarthrosis Model
White AP, Maak TG, Prince D, Vaccaro AR, Albert TJ, Hilibrand AS, Grauer JN. Osteogenic Protein-1 Induced Gene Expression: Evaluation in a Posterolateral Spinal Pseudarthrosis Model. Spine 2006, 31: 2550-2555. PMID: 17047543, DOI: 10.1097/01.brs.0000240713.24367.42.Peer-Reviewed Original ResearchConceptsGene expressionOsteogenic protein-1Protein 1Differential gene expressionGlyceraldehyde-3-phosphate dehydrogenaseGene expression dataBone morphogenetic protein-2Morphogenetic protein-2Platelet-derived growthExpression dataTranscriptase-polymerase chain reactionPolymerase chain reactionMolecular studiesProtein 2Messenger ribonucleic acidRibonucleic acidChain reactionAdhesion moleculesCytokine gene expressionExpressionGrowth factorVascular endothelial growth factorEnhanced levelsEndothelial growth factorReverse transcriptase-polymerase chain reaction
2005
Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1α
Dardik A, Yamashita A, Aziz F, Asada H, Sumpio BE. Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1α. Journal Of Vascular Surgery 2005, 41: 321-331. PMID: 15768016, DOI: 10.1016/j.jvs.2004.11.016.Peer-Reviewed Original ResearchConceptsSignal transduction pathwaysPlatelet-derived growth factorSMC chemotaxisCell signal transduction pathwaysMitogen-activated protein kinase pathwaySmooth muscle cell chemotaxisERK1/2 phosphorylationPDGF-BBExtracellular signal-regulated protein kinase 1/2Pathway inhibitor PD98059Protein kinase pathwayEndothelial cellsERK1/2 signal transduction pathwayProtein kinase 1/2Vascular smooth muscle cell migrationBovine aortic endothelial cellsKinase pathwayInhibitor PD98059Smooth muscle cell migrationHemodynamic forcesKinase 1/2Platelet-derived growthMuscle cell migrationWestern blot analysisTarget pathways
1998
The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament
Hildebrand K, Woo S, Smith D, Allen C, Deie M, Taylor B, Schmidt C. The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament. The American Journal Of Sports Medicine 1998, 26: 549-554. PMID: 9689377, DOI: 10.1177/03635465980260041401.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBecaplerminBiomechanical PhenomenaCell DivisionCollateral LigamentsDose-Response Relationship, DrugDrug CombinationsEpidermal Growth FactorExtracellular MatrixFibrin Tissue AdhesiveFibroblastsKnee InjuriesMaleMitogensPlatelet-Derived Growth FactorProto-Oncogene Proteins c-sisRabbitsRecombinant ProteinsRuptureTensile StrengthTransforming Growth Factor betaWeight-BearingWound HealingConceptsPlatelet-derived growth factor-BBMedial collateral ligament healingMedial collateral ligamentGrowth factor-BBPlatelet-derived growthCollateral ligamentGrowth factorFactor-BBLigament healingRight medial collateral ligamentFemur-medial collateral ligament-tibia complexRabbit medial collateral ligamentIndividual growth factorsHistologic evaluationHigh doseFibrin sealantControl groupHealing ligamentBiologic approachesFibroblast proliferationLigamentVitro workHealing tissueDosesHealing
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