Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs
Cohen J, D’Agostino L, Wilson J, Tuzer F, Torres C. Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs. Frontiers In Aging Neuroscience 2017, 9: 281. PMID: 28900395, PMCID: PMC5581874, DOI: 10.3389/fnagi.2017.00281.Peer-Reviewed Original ResearchHIV-Associated Neurocognitive DisordersHAART drugsHuman astrocytesDevelopment of HIV-associated neurocognitive disordersTreatment induced cell cycle arrestHIV-infected patientsMetabolic changesNeurocognitive disordersAntiretroviral therapy treatmentPrimary cultures of human astrocytesAntiretroviral therapy drugsCultures of human astrocytesCell cycle inhibitor p21Senescence-associated beta-galactosidaseInduction of reactive oxygen speciesAntiretroviral therapyMarkers of senescenceCell cycle arrestAstrocyte senescenceHAARTTherapy drugsPrimary culturesSurvival rateIncreased glycolysisNeurocognitive impairment
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