2018
microRNA Let‐7b: A Novel treatment for endometriosis
Sahin C, Mamillapalli R, Yi KW, Taylor HS. microRNA Let‐7b: A Novel treatment for endometriosis. Journal Of Cellular And Molecular Medicine 2018, 22: 5346-5353. PMID: 30063121, PMCID: PMC6201226, DOI: 10.1111/jcmm.13807.Peer-Reviewed Original ResearchConceptsLet-7bSide effectsSystemic hormonal side effectsMicroRNA let‑7bReproductive-aged womenHormonal side effectsTreatment of endometriosisCurrent treatment optionsChronic inflammatory diseaseSteroid hormone modulationGrowth factor receptorIL-6Treatment optionsEndometriosis growthEndometriosis pathophysiologyInflammatory diseasesChronic diseasesLocal treatmentPromising therapyMurine modelEndometriosisHormone modulationNovel treatmentsLesion sizeMicroRNAs treatments
2017
Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production
Nematian SE, Mamillapalli R, Kadakia TS, Zolbin M, Moustafa S, Taylor HS. Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production. The Journal Of Clinical Endocrinology & Metabolism 2017, 103: 64-74. PMID: 29040578, DOI: 10.1210/jc.2017-01199.Peer-Reviewed Original ResearchConceptsSera of patientsMacrophage cytokine productionIL-1βIL-6Cytokine productionIL-8Let-7bIL-1β levelsCytokine protein levelsU937 macrophage cell lineCase-control studyTumor necrosis factorLet-7b inhibitorReal-time polymerase chain reactionEnzyme-linked immunosorbentQuantitative real-time polymerase chain reactionMessenger RNA changesSystemic inflammationAberrant inflammationInflammatory cytokinesProinflammatory cytokinesLevels of microRNAsUniversity HospitalPolymerase chain reactionMacrophage cell line
2015
Circulating microRNAs as potential biomarkers for endometriosis
Cho S, Mutlu L, Grechukhina O, Taylor HS. Circulating microRNAs as potential biomarkers for endometriosis. Fertility And Sterility 2015, 103: 1252-1260.e1. PMID: 25772772, PMCID: PMC4417410, DOI: 10.1016/j.fertnstert.2015.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArea Under CurveCase-Control StudiesCell ProliferationEndometriosisFemaleGenetic MarkersHospitals, UniversityHumansLogistic ModelsMicroRNAsMiddle AgedPredictive Value of TestsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionROC CurveYoung AdultConceptsProliferative phaseLet-7bSerum CA-125 levelsMiR-135aCA-125 levelsSerum of womenBenign gynecologic diseaseCase-control studyQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionPotential noninvasive biomarkersLogistic regression modelsHighest areaGynecologic diseasePolymerase chain reactionUniversity HospitalMenstrual cycleEndometriosisMAIN OUTCOMENoninvasive biomarkersPotential biomarkersDiagnostic markerSerum samplesWomenChain reaction
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