2008
From Basic Science to Blockbuster Drug: The Discovery of Lyrica
Silverman R. From Basic Science to Blockbuster Drug: The Discovery of Lyrica. Angewandte Chemie International Edition 2008, 47: 3500-3504. PMID: 18307181, DOI: 10.1002/anie.200704280.Peer-Reviewed Original Research
1994
Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties
Gallo V, Patneau D, Mayer M, Vaccarino F. Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties. Glia 1994, 11: 94-101. PMID: 7927651, DOI: 10.1002/glia.440110204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsCells, CulturedCerebral CortexDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGenes, Immediate-EarlyGlutamic AcidImmediate-Early ProteinsKainic AcidMembrane PotentialsNerve Tissue ProteinsNeurotoxinsN-MethylaspartateOligodendrogliaRatsReceptors, GlutamateStem CellsTranscription FactorsConceptsCG-4 cellsAMPA receptor antagonist CNQXWhole-cell patch-clamp recordingsExcitatory amino acid receptorsProgenitor cellsAmino acid receptorsRat cerebral cortexPatch-clamp recordingsGlial progenitor cellsGlutamate receptor subunitsAgonists L-glutamateGlutamate-gated channelsImmediate early gene NGFIAntagonist CNQXCerebral cortexGABA antibodyPrimary cell linesGlutamate receptorsTransient elevationAcid receptorsReceptor subunitsOligodendrocyte lineageOligodendrocyte progenitorsL-glutamateKainate
1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatum
1989
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate
Burger P, Mehl E, Cameron P, Maycox P, Baumert M, Lottspeich F, De Camilli P, Jahn R. Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate. Neuron 1989, 3: 715-720. PMID: 2577130, DOI: 10.1016/0896-6273(89)90240-7.Peer-Reviewed Original ResearchConceptsSynaptic vesiclesRat cerebral cortexRat brain synaptic vesiclesProton electrochemical gradientBrain synaptic vesiclesCerebral cortexCytosolic poolMajor excitatory neurotransmitterVesicle membraneElectrochemical gradientAmino acidsVesiclesVesicle hypothesisMammalian CNSExcitatory neurotransmitterGlutamate lossEnrichment of glutamateN-ethylmaleimideStarting fractionGlutamate contentGlutamateHigh levelsL-glutamateCortexExchange experiments
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