Effectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis
Kumar D, Sabet H, Elshahat A, El-Moslemani M, Arafa A, Saleh M, Gamal S, Abbas A. Effectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2025, 1-16. PMID: 40613940, DOI: 10.1007/s00210-025-04414-2.Peer-Reviewed Original ResearchLennox-Gastaut syndromeLennox-Gastaut syndrome patientsSafety of perampanelAdverse eventsBehavioral adverse eventsLennox-GastautAdjunctive therapySeizure freedomResponder rateDiscontinuation due to lackSystematic reviewPooled responder ratesIndividual risk-benefit evaluationConfidence intervalsSeizure freedom ratesPooled incidence rateComplete seizure freedomMeta-analysis aimComprehensive literature searchRandom-effects modelRisk-benefit evaluationChi-square testFreedom ratesWeb of ScienceSeizure aggravation
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