2008
Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity
Cantone A, Yang X, Yan Q, Giebisch G, Hebert SC, Wang T. Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity. American Journal Of Physiology. Renal Physiology 2008, 294: f1366-f1372. PMID: 18385266, DOI: 10.1152/ajprenal.00608.2007.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAmilorideAnimalsBartter SyndromeCation Transport ProteinsChloridesDisease Models, AnimalDiureticsEpithelial Sodium ChannelsFemaleFurosemideGlomerular Filtration RateHydrochlorothiazideLoop of HenleMaleMiceMice, Mutant StrainsPotassium Channels, Inwardly RectifyingPregnancySodiumSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 1Up-RegulationConceptsThick ascending limbExcretion rateWhole kidney glomerular filtration rateKidney glomerular filtration rateFractional excretion rateFurosemide-induced incrementsGlomerular filtration rateType II Bartter's syndromeHyperprostaglandin E syndromeEffect of furosemideDistal nephron segmentsDistal convoluted tubuleExaggerated natriuresisROMK null miceNa excretionFiltration rateRenal saltAbsolute excretionBartter's syndromeE syndromeMouse modelClearance studiesConvoluted tubulesAscending limbNull mice
1994
Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat
Korutla L, Stewart G, Lasz E, Maione T, Niewiarowski S. Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat. Thrombosis And Haemostasis 1994, 71: 609-614. PMID: 8091389, DOI: 10.1055/s-0038-1642491.Peer-Reviewed Original ResearchConceptsRecombinant platelet factor 4Platelet factor 4Protamine sulfatePartial thromboplastin timeFactor 4Heparin clearanceHeparin neutralizationThromboplastin timeVitro additionClearance studiesDifferent physiological effectsAdverse effectsRatsOrgan depositionHeparinAnticoagulant activityPhysiological effectsGreater percentageLoss of radioactivityHalf lifeHeparin-agarose chromatographyInjectionMinLarge percentageRadioactivity
1986
Primary hyperparathyroidism in a dog: biochemical, bone histomorphometric, and pathologic findings.
Weir EC, Norrdin RW, Barthold SW, Meuten DJ, Pond MJ, Insogna KL. Primary hyperparathyroidism in a dog: biochemical, bone histomorphometric, and pathologic findings. Journal Of The American Veterinary Medical Association 1986, 189: 1471-4. PMID: 3804843, DOI: 10.2460/javma.1986.189.11.1471.Peer-Reviewed Original ResearchConceptsPrimary hyperparathyroidismEighth postoperative dayBlood biochemical findingsParathyroid gland adenomaIliac crest biopsiesBone histomorphometricRenal failurePostoperative daySurgical explorationPathologic findingsHistologic diagnosisClinical signsOval massCrest biopsiesGland adenomaBlunt dissectionClearance studiesBiochemical findingsHyperparathyroidismHistomorphometric analysisDiagnosisDogsTrabecular boneVeterinary cliniciansBone
1979
A micropuncture study of the renal handling of lithium
Hayslett J, Kashgarian M. A micropuncture study of the renal handling of lithium. Pflügers Archiv - European Journal Of Physiology 1979, 380: 159-163. PMID: 573443, DOI: 10.1007/bf00582152.Peer-Reviewed Original ResearchConceptsMicropuncture studiesProximal tubulesLoop of HenleTubular fluid samplesNephron sitesNet transepithelial movementRenal handlingLithium reabsorptionDistal tubulesClearance studiesTubular fluidProximal convolutionExperimental animalsDistal portionFluid samplesTubulesTransepithelial movementHenleNephron
1978
Effects of potassium depletion on renal tubular chloride transport in the rat
Luke R, Wright F, Fowler N, Kashgarian M, Giebisch G. Effects of potassium depletion on renal tubular chloride transport in the rat. Kidney International 1978, 14: 414-427. PMID: 35645, DOI: 10.1038/ki.1978.146.Peer-Reviewed Original ResearchConceptsEarly distal tubuleLoop of HenleDistal tubulesKD groupChloride reabsorptionProximal tubulesPotassium depletionAbsolute chloride reabsorptionAdministration of DOCASingle nephron GFRRenal tubular reabsorptionPotassium-depleted ratsLate distal tubuleEffects of KDNephron GFRTubular reabsorptionChloride intakeFractional reabsorptionClearance studiesDay 2Fractional deliveryMuscle potassiumWhole kidneyDay 9Rats
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