Mechanism of Impaired Potassium Transport in Pseudohypoaldosteronism
Wan L, Lessa L, Shen H, Malnic G, Giebisch G, Wang T. Mechanism of Impaired Potassium Transport in Pseudohypoaldosteronism. Physiology 2025, 40: 0956. DOI: 10.1152/physiol.2025.40.s1.0956.Peer-Reviewed Original ResearchMaxi-K channelsK+ secretionMaxi-KPseudohypoaldosteronism type IILate distal tubuleDistal tubulesHK intakeInhibitor iberiotoxinNaCl cotransporterDistal nephronNaCl reabsorptionConductance Ca2+-activated K+Thiazide-sensitive NaCl cotransporterCa2+-activated K+Renal outer medullary potassiumCortical distal tubulesRenal NaCl reabsorptionIncreased K+ secretionReduced NaCl reabsorptionWNK4 mutationsDouble-barreled microelectrodesChannel-mediated mechanismsNCC expression-activated K+WT mice
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